Pertussis antitoxin decay after vaccination with DTPa Response to a first booster dose 31/2-61/2 years after the third vaccine dose
Pertussis antitoxin decay after vaccination with DTPa Response to a first booster dose 31/2-61/2 years after the third vaccine dose
复制标题
DOI：
10.1016/j.vaccine.2005.06.009
复制
发表时间：
2005-11-16
期刊：
影响因子：
5.5
通讯作者：
Storsaeter, J
中科院分区：
文献类型：
--
作者：
Hallander, HO;Gustafsson, L;Storsaeter, J
纵向血清样本来自1992年至1995年参加瑞典百日咳疫苗试验的542名儿童[Gustafsson L，Hallander Ho，Olin P，Reizenstein E，Storsaeter J.一项双组分无细胞、五组分无细胞和全细胞百日咳疫苗的对照试验。N Engl J Med 1996；334(6)：349-355]且未感染百日咳。用ELISA法检测免疫后血清中百日咳抗体的衰变和抗百日咳毒素抗体(PT)的增强反应。一般情况下，抗毒素抗体浓度在开始时迅速下降，然后缓慢下降；当抗毒素几何平均水平达到8~9EL ISA单位/毫升(EU/mL)时，这种变化发生。在第2、4和6个月的计划中，达到这一水平所需的时间是在第三次接种后8-9个月。使用“最佳匹配”组合回归模型来预测何时50%的儿童抗-PT低于最低检测水平(1EU/mL)。这发生在6岁的第三次接种后约65个月。加强免疫后的抗PT反应很明显，但第三次接种后的几何平均值随着接种年限的增加而下降，并出现在较晚的时间。结果表明，学龄前加强免疫可能考虑在6岁或更早。(C)2005爱思唯尔有限公司。保留所有权利。
Longitudinal serum samples were collected from 542 children that had participated in a Swedish pertussis vaccine trial 1992-1995 [Gustafsson L, Hallander HO, Olin P, Reizenstein E, Storsaeter J. A controlled trial of a two-component acellular, a five-component acellular, and a whole-cell pertussis vaccine. N Engl J Med 1996;334(6):349-355] and who did not contract pertussis. The sera were analyzed for post vaccination antibody decay and for booster response of anti-PT (IgG antibodies against pertussis toxin), as measured by ELISA.Generally, an initial rapid decay of antitoxin antibody concentration was followed by a slower decay; the change occurring when the geometric mean level of antitoxin concentration reached 8-9 ELISA Units/mL (EU/mL). The time needed to reach this level was 8-9 months after the third dose in a 2, 4, and 6 months schedule.A "best-fit" combined regression model was used to predict when 50% of the children have less than the minimum level of detection of anti-PT (1 EU/mL). This occurred about 65 months after dose 3 at an age of 6 years.The anti-PT response to a booster dose was evident but the post-booster geometric mean values decreased with number of years after the third dose and the response appeared later.The results indicate that a pre-school booster might be considered at 6 years of age or earlier. (c) 2005 Elsevier Ltd. All rights reserved.