Structure of the peptidoglycan of bacterial spores: occurrence of the lactam of muramic acid.
Structure of the peptidoglycan of bacterial spores: occurrence of the lactam of muramic acid.
复制标题
细菌孢子肽聚糖的结构：胞壁酸内酰胺的出现。
DOI：
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发表时间：
1969
影响因子：
11.1
通讯作者：
J. Strominger
中科院分区：
文献类型：
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作者：
A. D. Warth;J. Strominger
枯草芽孢杆菌芽孢肽聚糖经溶菌酶处理后释放出六种主要的寡糖。它们被分离和表征为二糖，四糖，和六糖组成的等量的胞壁酸和氨基葡萄糖，并含有两个，三个和四个乙酰基，分别。其中三种化合物被单个L-丙氨酸残基取代，另外三种被每个化合物还原端的乙酰胞壁酸残基上的单个四肽取代基取代。四糖中的其他胞壁酸残基（以及六糖中的三个中的两个）被证明是以胞壁内酰胺的形式存在的，这是一种以前在自然界中未发现的糖，因此是一种独特的孢子成分。孢子肽聚糖的结构的其他功能进行了讨论。
Six major oligosaccharides were released from the peptidoglycan of spores of Bacillus subtilis by lysozyme treatment. They were isolated and characterized as a disaccharide, tetrasaccharide, and hexasaccharide composed of equal amounts of muramic acid and glucosamine and containing two, three, and four acetyl groups, respectively. Three of the compounds were substituted by a single L-alanine residue, and the other three by a single tetrapeptide substituent on the acetylmuramic acid residue at the reducing end of each compound. The other muramic acid residue in the tetrasaccharides (and two of the three in the hexasaccharides) were shown to be present as muramic lactams, a sugar not previously found in nature and, hence, a unique spore constituent. Other features of the structure of spore peptidoglycan are discussed.