Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
Serum markers for predicting significant necroinflammatory activity in patients with chronic hepatitis B
复制标题
DOI：
10.1016/j.clinbiochem.2012.07.107
复制
发表时间：
2012-12-01
影响因子：
2.8
通讯作者：
Cheong, Jae Youn
中科院分区：
文献类型：
--
作者：
Cho, Hyo Jung;Kim, Soon Sun;Cheong, Jae Youn
目的：本研究的目的是确定预测慢性B型肝炎（CH B）患者显著炎症的血清标志物。设计和方法：在2005年10月至2009年6月期间，纳入了384例CH B患者。多元逻辑回归分析确定了ALT，透明质酸（HA）和Ⅲ型前胶原N-末端肽（PIIINP）作为显著炎症（≥ 3级）的独立预测因子。我们构建了一个预测严重炎症的公式。显著炎症（SI）评分= 1.773 x ALT评分+1.599 x PIIINP评分+0.677 x HA评分-1.962。SI评分的受试者工作特征曲线下面积为0.831。SI评分的敏感性、特异性、阳性预测值和阴性预测值分别为79.5%、70.8%、76.8%和74.3%。PIIINP和HA是CHB患者显著炎症活动的准确非侵入性预测因子。(C)2012年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objectives: The aim of this study was to determine the serum markers that predict significant inflammation in patients with chronic hepatitis B (CHB).Design and methods: Between October 2005 and June 2009, 384 subjects with CHB were enrolled.Results: Multiple logistic regression analysis identified the ALT, hyaluronic acid (HA) and procollagen III N-terminal peptide (PIIINP) as independent predictors of significant inflammation (grade >= 3). We constructed a formula for predicting significant inflammation. A significant inflammation (SI) score=1.773 x ALT score+1.599 x PIIINP score+0.677 x HA score-1.962. The area under receiver operating characteristic curve of the SI score was 0.831. The sensitivity, specificity, positive predictive value and negative predictive value of the SI score were 79.5%, 70.8%, 76.8% and 74.3%, respectively.Conclusions: A simple scoring system including ALT. PIIINP and HA is an accurate non-invasive predictor of significant inflammatory activities in patients with CHB. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.