Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy.
Mechanisms of Tumor Growth Inhibition by Depletion of γ-Glutamylcyclotransferase (GGCT): A Novel Molecular Target for Anticancer Therapy.
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DOI：
10.3390/ijms19072054
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发表时间：
2018-07-14
影响因子：
5.6
通讯作者：
Nakata S
中科院分区：
文献类型：
--
作者：
Kageyama S;Ii H;Taniguchi K;Kubota S;Yoshida T;Isono T;Chano T;Yoshiya T;Ito K;Yoshiki T;Kawauchi A;Nakata S
γ-谷氨酰环转移酶 (GGCT) 是参与谷胱甘肽代谢的主要酶之一，在多种癌症（胶质瘤、乳腺癌、肺癌、食道癌、胃癌、结直肠癌、膀胱癌、前列腺癌、宫颈癌、卵巢癌和骨肉瘤）中表达上调，并促进癌症进展；它的耗尽会抑制癌细胞的增殖、侵袭和迁移。已经证明抑制或抑制GGCT在荷癌异种移植小鼠中具有抗肿瘤作用。基于这些观察，GGCT 现在被认为是多种癌症的有前途的治疗靶点。本文综述了 GGCT 抑制的抗肿瘤活性机制的最新进展。
γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers—glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma—and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of cancer cells. It has been demonstrated that the suppression or inhibition of GGCT has an antitumor effect in cancer-bearing xenograft mice. Based on these observations, GGCT is now recognized as a promising therapeutic target in various cancers. This review summarizes recent advances on the mechanisms of the antitumor activity of GGCT inhibition.
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影响因子：
3.8
作者：
Matsumura K;Nakata S;Taniguchi K;Ii H;Ashihara E;Kageyama S;Kawauchi A;Yoshiki T
通讯作者：
Yoshiki T
影响因子：
2.3
作者：
Dong, Jian;Zhou, Yuanhang;Li, Yue
通讯作者：
Li, Yue
影响因子：
6.1
作者：
Nakamura, Yukiko K.;Dubick, Michael A.;Omaye, Stanley T.
通讯作者：
Omaye, Stanley T.
影响因子：
5.4
作者：
Ohno, Yuji;Hattori, Akira;Kakeya, Hideaki
通讯作者：
Kakeya, Hideaki
DOI：
10.1016/j.bbrc.2006.05.161
发表时间：
2006-07-28
影响因子：
3.1
作者：
Masuda, Yutaka;Maeda, Sayoko;Nakaya, Kazuyasu
通讯作者：
Nakaya, Kazuyasu