High-throughput study of poly(ethylene glycol)/ibuprofen formulations under controlled environment using FTIR imaging
High-throughput study of poly(ethylene glycol)/ibuprofen formulations under controlled environment using FTIR imaging
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DOI：
10.1021/cc050041x
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发表时间：
2006-01-01
影响因子：
--
通讯作者：
Kazarian, SG
中科院分区：
文献类型：
--
作者：
Chan, KLA;Kazarian, SG
在相同条件下同时分析多个样品可提高研究效率并加速产品设计。一种新的光谱成像方法，使用多通道检测器已被开发用于在受控环境下的药物制剂的并行分析。使用微滴沉积方法制备布洛芬在聚（乙二醇）中的制剂样品，其中布洛芬浓度范围为0至100%。布洛芬在PEG中的浓度，在该浓度下可以避免布洛芬分子的二聚化，已经通过使用原位FTIR光谱成像同时测量所有样品来确定。对所有样品的FTIR光谱进行了分析，以评估药物的分子状态和聚合物溶胀度随药物浓度的变化。还研究了升高的温度对所有制剂的稳定性的影响。这种高通量方法确定了稳定制剂的浓度范围，并提供了证据表明布洛芬和聚合物之间的氢键是提高高温稳定性的原因。这种基于微型采样系统的高通量成像方法通过允许并行运行许多（可能几千个）实验来显著减少实验时间，并通过最小化实验之间的变化来提高准确性。
Simultaneous analysis of many samples under identical conditions improves the effectiveness of research and accelerates product design. A novel spectroscopic imaging approach using a multichannel detector has been developed for parallel analysis of pharmaceutical formulations under controlled environments. Samples of formulations of ibuprofen in poly(ethylene glycol) have been prepared with ibuprofen concentrations ranging from 0 to 100% using a microdroplet deposition approach. The concentration of ibuprofen in PEG at which dimerization of ibuprofen molecules can be avoided has been determined via simultaneous measurement of all samples using in situ FTIR spectroscopic imaging. FTIR spectra from all samples have been analyzed to assess the molecular state of the drug and the degree of polymer swelling as a function of drug concentration. The effect of elevated temperature on the stability of all formulations was also studied. This high-throughput approach identified the concentration range for stable formulations and provided evidence that hydrogen bonding between ibuprofen and the polymer is responsible for enhanced stability at higher temperatures. This high-throughput imaging approach, based on a miniature sampling system, significantly reduces the experimental time by allowing many (potentially a few thousand) experiments to be run in parallel and increases the accuracy by minimizing variations between experiments.