Urinary iodine concentration follows a circadian rhythm: A study with 3023 spot urine samples in adults and children
Urinary iodine concentration follows a circadian rhythm: A study with 3023 spot urine samples in adults and children
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DOI：
10.1210/jc.85.4.1367
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发表时间：
2000-04-01
影响因子：
5.8
通讯作者：
Gerber, H
中科院分区：
文献类型：
--
作者：
Als, C;Helbling, A;Gerber, H
我们的总体目标是在一项前瞻性研究中监测1998年9月瑞士碘盐含量增加前后的碘供应情况。由于碘是由营养提供的，我们还想知道尿碘浓度(UI)是否受昼夜节律的控制。42名受试者(18名男性和24名女性，包括13名儿童)在1996年5月至1998年5月期间采集了3023个尿点，每月3至5个样本，每天的任何时间。结果表明，成人和儿童尿失禁的昼夜节律性与个体、年龄、性别和季节无关。UI值在8~11h最低，12~24h呈递增曲线。UT仅在21-22小时内恢复到基线水平。尿失禁高峰出现在主餐后4~5h，儿童尿失禁高峰出现晚于成人。尽管尿失禁昼夜节律的存在可能是普遍存在的，但其形状取决于营养。因为早上的斑点代表了UI的最低点，所以这似乎是一个合适的收集期。鉴于尿路的显著昼夜节律性，例如，将采样时间限制在上午数小时的研究不能直接与全天采样尿液的研究相比较。
Our overall aim is to monitor iodine supply in a prospective study before and after the September 1998 increase of salt iodide content in Switzerland. Because iodide is supplied by alimentation, we moreover wondered whether urinary iodine concentration (UI) is governed by circadian rhythmicity.Forty-two subjects (18 males and 24 females, including 13 children) collected 3023 urine spots between May 1996 and May 1998, at a rate of three to five samples per month, at any time of the day. The results show that circadian rhythmicity of UI in adults and children was found independent of the individual subject, age, gender, and season. Lowest UI levels were found between 8-11 h. A curve increasing progressively between 12 and 24 h was obtained. UT returned to base-line levels between 21 and 22 h in children only. UI peaks occurred 4-5 h after main meals; children's peaks occurred later than that of adults.Although the existence of a circadian rhythm of UI is probably universal, its profile, however, depends on alimentation. Because nadir of UI is represented by morning spots, this might seem an appropriate collecting period. In view of the significant circadian rhythmicity of UI, studies with restriction of sampling time to morning hours, for example, cannot be directly compared with studies in which urine is sampled all over the day.