Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression
Elevation of synaptic protein is associated with the antidepressant-like effects of ferulic acid in a chronic model of depression
复制标题
在慢性抑郁症模型中，突触蛋白的升高与阿魏酸的抗抑郁样作用有关
DOI：
10.1016/j.physbeh.2016.12.003
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发表时间：
2017-02-01
影响因子：
2.9
通讯作者：
Yi, Li-Tao
中科院分区：
文献类型：
--
作者：
Liu, Ya-Min;Hu, Chun-Yue;Yi, Li-Tao
阿魏酸是一种羟基肉桂酸，广泛存在于植物细胞壁成分中。在强迫游泳实验和悬尾实验中，阿魏酸均能逆转抑郁样行为。然而，慢性阿魏酸治疗是否能改善慢性不可预测的轻度应激(CUMS)患者的抑郁样行为尚不清楚。鉴于神经营养系统与抗抑郁药样活性之间的可能关系，我们还研究了慢性阿魏酸对前额叶皮质和海马区脑源性神经营养因子(BDNF)、突触后蛋白PSD95、突触前蛋白突触蛋白I的影响。结果表明，阿魏酸能明显减轻CUMS诱导的小鼠在蔗糖偏好实验和强迫游泳实验中的抑郁样行为。此外，阿魏酸显著上调前额叶皮质和海马区BDNF、PSD95和突触素I的水平。目前的数据表明，阿魏酸通过增加神经营养素相关突触蛋白的水平，对CUMS小鼠的行为起到了抗抑郁药的作用。(C)2016 Elsevier Inc.保留所有权利。
Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components. It has been demonstrated that ferulic acid can reverse depressive-like behaviors in both forced swimming test and tail suspension test. However, it is undear whether chronic ferulic acid treatment can ameliorate the depressive-like behaviors in chronic unpredictable mild stress (CUMS). Because of the putative relationship between neurotrophic system and antidepressant-like activity, we also investigated the effects of chronic ferulic acid on the brain-derived neurotrophic factor (BDNF), postsynaptic protein PSD95, presynaptic protein synapsin I in both prefrontal cortex and hippocampus. The results showed that ferulic acid significantly alleviated CUMS-induced depressive-like behaviors in sucrose preference test and forced swimming test. In addition, ferulic acid significantly up-regulated the levels of BDNF, PSD95 and synapsin I in the prefrontal cortex and hippocampus. The present data indicated that ferulic acid exerted the antidepressant-like effects on behaviors by increasing neurotrophin-related synaptic protein levels in CUMS mice. (C) 2016 Elsevier Inc. All rights reserved.