Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women
Prospective cohort study of soy food consumption and risk of bone fracture among postmenopausal women
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DOI：
10.1001/archinte.165.16.1890
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发表时间：
2005-09-12
影响因子：
--
通讯作者：
Zheng, W
中科院分区：
文献类型：
--
作者：
Zhang, XL;Shu, XO;Zheng, W
Background: Soy consumption has been shown to modulate bone turnover and increase bone mineral density in postmenopausal women. To our knowledge, no published studies have directly examined the association between soy consumption and risk of fracture.Methods: We examined the relationship between usual soy food consumption and fracture incidence in 24 403 postmenopausal women who had no history of fracture or cancer and were recruited between March 1, 1997, and May 23, 2000, in the Shanghai Women's Health Study, a cohort study of approximately 75 000 Chinese women aged 40 to 70 years. Usual soy food intake was assessed at baseline and reassessed during follow-up through in-person interviews using a validated food frequency questionnaire. Outcomes were ascertained by biennial in-person interview surveys.Results: During a mean follow-up of 41/2 years (110 243 person-years), 1770 incident fractures were identified. After adjustment for age, major risk factors of osteoporosis, socioeconomic status, and other dietary factors, the relative risks (95% confidence intervals) of fracture were 1.00, 0.72 (0.62-0.83), 0.69 (0.59-0.80), 0.64 (0.55-0.76), and 0.63 (0.53-0.76) across quintiles of soy protein intake (P
