Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.
Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.
复制标题
GABA 和挥发性麻醉剂在线虫秀丽隐杆线虫中的相互作用。
DOI：
10.1096/fasebj.4.8.2335273
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Sedensky,MM
中科院分区：
文献类型：
--
作者：
Boswell,MV;Morgan,PG;Sedensky,MM
The authors tested whether mutant strains ofCaenorhabditis eleganswith altered sensitivity to volatile anesthetics have altered responses to GABA or GABA‐agonists. They determined the ED50s of the wild‐type strain N2 and two mutant strains ofC. elegansto a GABA‐mimetic ivermectin (IVM) and to GABA.unc‐79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA.unc‐9, a strain that suppresses the increased sensitivity ofunc‐79to halothane, was less sensitive than N2 to IVM and GABA. The authors also tested whether doses of GABA or IVM and volatile anesthetics were additive in their effects onC. elegans.Halothane (2.1%) did not shift the ED50of IVM, but was antagonistic to GABA. Enflurane (4%) was antagonistic to both IVM and GABA. However, ED50s of halothane and enflurane were unchanged in the presence of IVM (35 nM) or GABA (150 mM). The authors conclude that GABA by itself does not appear to mediate halothane or enflurane sensitivity inC. elegans.— Boswell, M. V.; Morgan, P. G.; Sedensky, M. M. Interaction of GABA and volatile anesthetics in the nematodeCaenorhabditis elegans. FASEB J.4: 2506‐2510; 1990.
