Molecular mobility of interlocked structures exploiting new functions of advanced biomaterials
Molecular mobility of interlocked structures exploiting new functions of advanced biomaterials
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DOI：
10.1002/chem.200600370
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发表时间：
2006-09-06
影响因子：
4.3
通讯作者：
Ooya, Tooru
中科院分区：
文献类型：
--
作者：
Yui, Nobuhiko;Ooya, Tooru
环状化合物可以在聚轮烷结构中沿着聚合物链旋转和/或沿着滑动，并且由环状化合物连接的配体的移动性与增强与受体蛋白上的结合位点的多价相互作用密切相关。这一概念正在生物医学和制药领域的更实际应用中得到利用，例如非病毒基因载体。
Cyclic compounds can rotate and/or slide along a polymeric chain in a polyrotaxane structure, and the mobility of the ligands linked by the cyclic compounds is closely related to enhancing the multivalent interaction with binding sites on the receptor proteins. This concept is being exploited in more practical applications in the biomedical and pharmaceutical fields, such as a non-viral gene carriers.