Pt(II)- or Au(III)-catalyzed [3+2] cycloaddition of metal-containing azomethine ylides: Highly efficient synthesis of the mitosene skeleton
Pt(II)- or Au(III)-catalyzed [3+2] cycloaddition of metal-containing azomethine ylides: Highly efficient synthesis of the mitosene skeleton
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DOI：
10.1021/ol052610f
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发表时间：
2006-01-19
期刊：
影响因子：
5.2
通讯作者：
Iwasawa, N
中科院分区：
文献类型：
--
作者：
Kusama, H;Miyashita, Y;Iwasawa, N
仅1-3 mol%的PtCl(2)或AuBr(3)就足以促进源自带有内部炔部分的M(邻炔基苯基)亚胺的含过渡金属的甲亚胺叶立德的生成和[3+2]环加成。该方法建立了一种高效制备合成有用的吲哚核3位具有取代基的三环吲哚衍生物的方法。
Only 1-3 mol % of PtCl(2) or AuBr(3) was sufficient to promote generation and [3+2] cycloaddition of transition-metal-containing azomethine ylides derived from M(o-alkynylphenyl)imines bearing an internal alkyne moiety. A highly efficient method for the preparation of synthetically useful tricyclic indole derivatives having a substituent at the 3-position of the indole nucleus was established by this method.