The pattern of breathing in acute severe asthma.
The pattern of breathing in acute severe asthma.
复制标题
急性重症哮喘的呼吸模式。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
Kevin E. Finucane
中科院分区：
文献类型：
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作者：
David R. Hillman;L. Prentice;Kevin E. Finucane
对8例急性重症哮喘患者入院时及恢复期的呼吸模式进行了研究，以确定胸壁运动随气流阻塞程度的变化，以及气流阻塞程度与呼吸时机和呼吸机的关系，以及在哮喘最严重时这种呼吸模式是否提示呼吸肌疲劳。通过同时测量下肋骨和腹部的呼吸量(呼吸速度图)和前后运动(AP)(磁强计)来评估模式。在FEV1最低的患者中，AP肋骨相对于AP腹壁运动的相位滞后最大，在恢复过程中逐渐减小。重度哮喘患者吸气时间明显缩短。平均吸气流量在中度哮喘患者中增加，但当FEV1低于预测的25%时降低。呼吸模式在严重哮喘期间和在恢复期间没有更多的变化。我们的结论是，在重度急性呼吸窘迫时，胸廓相对于腹壁运动的相位滞后程度反映了哮喘的严重程度；呼吸驱动增加，但与低于预计的25%FEV1的通气量增加无关，对呼吸模式的分析没有提供呼吸肌疲劳的明确证据。
The pattern of breathing was studied in 8 patients with acute severe asthma on admission to hospital and during recovery to determine how chest wall motion varied with the degree of air-flow obstruction (AO), the relationship between degree of AO and respiratory timing and ventilation, and whether the pattern suggested respiratory muscle fatigue when asthma was most severe. Pattern was assessed by simultaneous measurement of respired volumes (pneumotachygraph) and anteroposterior (AP) motion of lower rib cage and abdomen (magnetometers). There was a phase lag of AP rib cage relative to AP abdominal motion that was greatest in those with lowest FEV1 and progressively decreased during recovery. Fractional inspiratory time was decreased in severe asthma. Mean inspiratory flow was increased in moderately severe asthma but decreased when FEV1 was less than 25% predicted. Breathing pattern was no more variable during severe asthma than during recovery. We conclude that during severe AO the magnitude of phase lag of AP rib cage relative to AP abdominal motion reflects severity of asthma; respiratory drive is increased but is not associated with increased ventilation below an FEV1 of 25% predicted, and analysis of the breathing pattern provides no clear evidence of respiratory muscle fatigue.