Meeting report from the 10th International Congress of the Society for Melanoma Research, Philadelphia, PA, November 2013.
Meeting report from the 10th International Congress of the Society for Melanoma Research, Philadelphia, PA, November 2013.
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黑色素瘤研究学会第十届国际大会的会议报告，宾夕法尼亚州费城，2013 年 11 月。
DOI：
10.1111/pcmr.12240
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发表时间：
2014
影响因子：
4.3
通讯作者：
Weeraratna,AshaniT
中科院分区：
文献类型：
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作者：
Vultur,Adina;O'Connell,Michael;Webster,Marie;Villanueva,Jessie;Herlyn,Dorothee;Somasundaram,Rajasekharan;Krepler,Clemens;Zaidi,Raza;Patton,Elizabeth;Sekulic,Aleksander;Jonsson,Goran;Weeraratna,AshaniT
今年的SMR在宾夕法尼亚州费城举行。这是该协会成立十周年的庆祝活动，约有800名注册会员参加，这是一个破纪录的数字。会议以马萨诸塞州波士顿哈佛医学院的Joan Brugge的主旨演讲开始。布鲁格博士是一位著名的乳腺癌研究人员，她向我们展示了她的三维细胞培养模型如何帮助我们更好地了解组织状环境中的细胞如何对治疗做出反应和抵抗。位于乳房球体外边缘的细胞，即与其细胞外基质保持接触的细胞，对治疗的反应不如位于球体中心的细胞。RPPA研究表明，肿瘤细胞如何改变它们的信号以克服附着的丧失，而靶向这些途径可能是诱导肿瘤细胞死亡的一种有效方式。接下来，马萨诸塞州波士顿马萨诸塞州总医院的David Fisher讨论了调节黑色素瘤形成和生存的途径，并展示了紫外线如何通过上调MSH和β-内啡肽来触发阳光寻找行为。一种阿片类拮抗剂甚至会引起慢性紫外线照射小鼠的戒断症状。最后的焦点是黑素皮质素受体、阿片受体、cAMP之间的信号和对痛阈值的影响(表明红发患者的痛阈值更高)，以及吗啡似乎如何作为MC4R受体的拮抗剂；这些研究可能会导致新的止痛策略。
This year’s SMR took place in Philadelphia, PA. This was the tenth anniversary celebration of the Society’s formation and was attended by about 800 registrants, a record-breaking number. The meeting opened with a keynote talk from Joan Brugge (Harvard Medical School, Boston, MA). Dr. Brugge, a noted breast cancer researcher, showed us how her three-dimensional cell culture models can help us better understand how cells in a tissue-like environment respond and resist to therapy. Cells at the outer edges of the breast spheroids or ‘acini’, that is, cells that remained in contact with their extracellular matrix, did not respond to therapy as well as those in the center of the spheroids. RPPA studies showed how tumor cells alter their signaling to overcome the loss of attachment and targeting these pathways could be a potent way of inducing death in tumor cells. The dynamic reprogramming of the kinome in response to MEK inhibition in triple-negative breast cancer was also explored.Next, David Fisher (Massachusetts General Hospital, Boston, MA) discussed pathways that modulate melanoma formation and survival and showed how UV triggers a sun-seeking behavior through upregulation of MSH and beta-endorphin. An opiate antagonist even caused withdrawal symptoms in chronic UV-irradiated mice. The final focus was on the signaling between the melanocortin receptor, opioid receptor, cAMP, and effects on pain threshold (suggesting that redheads have a higher pain threshold) and how morphine appears to act as an antagonist of the MC4R receptor; these studies may lead to new pain relief strategies.