The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial.
The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial.
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在有意识的静息状态下，健康老年人中富含黄酮醇的可可醇对脑灌注的影响：安慰剂控制，跨界，急性试验。
DOI：
10.1007/s00213-015-3972-4
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发表时间：
2015-09
影响因子：
3.4
通讯作者：
Butler LT
中科院分区：
文献类型：
--
作者：
Lamport DJ;Pal D;Moutsiana C;Field DT;Williams CM;Spencer JP;Butler LT
最近，人们对黄烷醇的潜力越来越感兴趣，黄烷醇是水果和蔬菜等食物中发现的植物衍生化合物，可以改善与年龄相关的认知能力下降。研究表明，可可黄烷醇改善记忆和学习，可能是由于其抗炎和神经保护作用。这些作用可能是通过增加脑血流量（CBF）介导的，从而刺激神经元功能。本研究采用动脉自旋标记功能磁共振成像，探讨单次急性剂量的可可黄烷醇对局部脑血流的影响。根据随机平衡交叉双盲设计，在年龄50-65岁的8名男性和10名女性中，测量了低（23 mg）或高（494 mg）330 ml与咖啡因、可可碱、味道和外观相匹配的当量黄烷醇饮料饮用前后的CBF。从消费前到消费后的灌注变化计算为每种饮料的函数。相对于低黄烷醇饮料，饮用高黄烷醇饮料后观察到大脑局部灌注显着增加，特别是在顶叶的前扣带回皮质和中央盖层皮质中。食用可可黄烷醇改善老年人局部脑灌注。这为可可黄烷醇与认知表现益处相关的可能急性机制提供了证据。
There has recently been increasing interest in the potential of flavanols, plant-derived compounds found in foods such as fruit and vegetables, to ameliorate age-related cognitive decline. Research suggests that cocoa flavanols improve memory and learning, possibly as a result of their anti-inflammatory and neuroprotective effects. These effects may be mediated by increased cerebral blood flow (CBF), thus, stimulating neuronal function. The present study employed arterial spin labelling functional magnetic resonance imaging to explore the effect of a single acute dose of cocoa flavanols on regional CBF. CBF was measured pre- and post-consumption of low (23 mg) or high (494 mg) 330 ml equicaloric flavanol drinks matched for caffeine, theobromine, taste and appearance according to a randomized counterbalanced crossover double-blind design in eight males and ten females, aged 50–65 years. Changes in perfusion from pre- to post-consumption were calculated as a function of each drink. Significant increases in regional perfusion across the brain were observed following consumption of the high flavanol drink relative to the low flavanol drink, particularly in the anterior cingulate cortex and the central opercular cortex of the parietal lobe. Consumption of cocoa flavanol improves regional cerebral perfusion in older adults. This provides evidence for a possible acute mechanism by which cocoa flavanols are associated with benefits for cognitive performance.