Changes in conjunctival cytology and tear function tests with radioiodine treatment for hyperthyroidism
Changes in conjunctival cytology and tear function tests with radioiodine treatment for hyperthyroidism
复制标题
放射性碘治疗甲状腺功能亢进症时结膜细胞学和泪液功能测试的变化
作者：
G. Koca;U. Acar;H. Atilgan;Damla Ergintürk Acar;U. Altıparmak;K. Demirel;Z. Yalniz;H. Ustun;M. Korkmaz;F. Ornek
目的放射性碘（RAI）用于治疗甲状腺功能亢进症和分化型甲状腺癌。放射性碘治疗与干眼症有关，特别是由于β射线，可以看到一些副作用。在这项研究中，RAI治疗后泪腺的功能和细胞学状态进行了evaluated.MethodsTwenty-five患者的平均年龄为55.16岁，计划低剂量RAI治疗进行了评价。治疗前及治疗后6个月分别进行泪膜破裂时间（BUT）、泪液分泌试验（Schirmer's test）、泪膜印迹细胞学检查及“眼表疾病指数（OSDI）”问卷调查。结果治疗前右眼泪液分泌试验平均值为16.20 ± 3.61，治疗后平均值为11.28 ± 4.39;左眼分别为15.76 ± 3.27和10.60 ± 4.42。治疗后双眼的Schirmer检验平均值显著降低（p = 0.0001）。治疗后BUT评分也显著降低（p = 0.001）。治疗前OSDI评分平均值为27.5 ± 8.02，治疗后为46.36 ± 10.27。治疗后OSDI评分的平均值增加（p = 0.0001）。治疗后两眼的印象评分也增加（p = 0.0001）。结论即使是低剂量（≤30 mci）RAI治疗也会影响泪腺功能。低剂量RAI可引起Schirmer试验和BUT试验值降低，OSDI评分和印象评分值升高。
ObjectivesRadioiodine (RAI) is used in the treatment of hyperthyroidism and differentiated thyroid cancer. Radioiodine therapy is associated with dry eyes and some side effects are seen especially due to beta rays. In this study, the functional and cytological status of lacrimal glands after RAI therapy was evaluated.MethodsTwenty-five patients with a mean age of 55.16 years with planned low-dose RAI therapy were evaluated. Just before and 6 months after the treatment, the lacrimal glands were evaluated with tear break-up time (BUT), Schirmer’s test, impression cytology and “Ocular Surface Disease Index (OSDI)” questionnaire.ResultsThe mean value of Schirmer’s test was 16.20 ± 3.61 pre-treatment and 11.28 ± 4.39 post-treatment for the right eye, and 15.76 ± 3.27 and 10.60 ± 4.42 for the left eye, respectively. The mean value of Schirmer’s test decreased significantly post-treatment in both eyes (p = 0.0001). The BUT score also decreased significantly post-treatment (p = 0.001). The mean value of OSDI score was 27.5 ± 8.02 pre-treatment and 46.36 ± 10.27 post-treatment. The mean value of OSDI score increased post-treatment (p = 0.0001). The impression scores also increased post-treatment in both eyes (p = 0.0001).ConclusionEven low-dose (≤30 mci) RAI treatment affects lacrimal gland functions. Low-dose RAI causes a decrease in the value of Schirmer’s test and the BUT test, and an increase in the value of OSDI score and impression scores.
眼附属器急性放射损伤。
DOI：
10.1001/archopht.1988.01060130415032
发表时间：
1988
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Stephens,LC;Schultheiss,TE;Peters,LJ;Ang,KK;Gray,KN
通讯作者：
Gray,KN
DOI：
10.1016/0360-3016(92)90716-u
发表时间：
1992-01-01
影响因子：
7
作者：
GAZDA, MJ;SCHULTHEISS, TE;PETERS, LJ
通讯作者：
PETERS, LJ