A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.
A Federated Network for Translational Cancer Research Using Clinical Data and Biospecimens.
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DOI：
10.1158/0008-5472.can-15-1973
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发表时间：
2015-12-15
期刊：
影响因子：
11.2
通讯作者：
Weaver J
中科院分区：
文献类型：
--
作者：
Jacobson RS;Becich MJ;Bollag RJ;Chavan G;Corrigan J;Dhir R;Feldman MD;Gaudioso C;Legowski E;Maihle NJ;Mitchell K;Murphy M;Sakthivel M;Tseytlin E;Weaver J
癌症研究和个性化医疗的进步将需要重要的新桥梁基础设施，包括将人体组织与临床表型和结果联系起来的更强大的生物储存库。为了应对这一挑战，四个癌症中心组成了TIES癌症研究网络，这是一个联合网络，旨在促进成员机构之间的数据和生物标本共享。成员研究中心可以访问使用TIES自然语言处理系统进行去识别和处理的病理学数据，该系统创建了与临床生物标本相关的丰富表型数据库。TIES结合了多种安全和隐私最佳实践，与法律的协议、网络策略和程序相结合，实现了法规遵从性。TIES癌症研究网络现在为所有成员机构的研究人员提供综合访问，这些机构正在进行多个由制药商驱动的试点项目。跨网络的联合搜索的例子说明了对转化研究的潜在影响，特别是对于涉及罕见癌症、罕见表型和特定生物学行为的研究。该网络满足了几个关键的desiderata，包括本地控制的数据和认证，包括丰富的表型信息，并适用于不同的研究目标。TIES癌症研究网络为国家数据和生物标本网络提供了一个模型。
Advances in cancer research and personalized medicine will require significant new bridging infrastructures, including more robust biorepositories that link human tissue to clinical phenotypes and outcomes. In order to meet that challenge, four cancer centers formed the TIES Cancer Research Network, a federated network that facilitates data and biospecimen sharing among member institutions. Member sites can access pathology data that is de-identified and processed with the TIES natural language processing system, which creates a repository of rich phenotype data linked to clinical biospecimens. TIES incorporates multiple security and privacy best practices that, combined with legal agreements, network policies and procedures, enable regulatory compliance. The TIES Cancer Research Network now provides integrated access to investigators at all member institutions, where multiple investigator-driven pilot projects are underway. Examples of federated search across the network illustrate the potential impact on translational research, particularly for studies involving rare cancers, rare phenotypes, and specific biologic behaviors. The network satisfies several key desiderata including local control of data and credentialing, inclusion of rich phenotype information, and applicability to diverse research objectives. The TIES Cancer Research Network presents a model for a national data and biospecimen network.