Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial
Effects of Resveratrol on Polycystic Ovary Syndrome: A Double-blind, Randomized, Placebo-controlled Trial
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DOI：
10.1210/jc.2016-1858
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发表时间：
2016-11-01
影响因子：
5.8
通讯作者：
Duleba, Antoni J.
中科院分区：
文献类型：
--
作者：
Banaszewska, Beata;Wrotynska-Barczynska, Joanna;Duleba, Antoni J.
背景：多囊卵巢综合征（PCOS）是影响育龄妇女最常见的内分泌疾病。高雄激素血症是PCOS的中心特征。对卵巢卵泡膜间质细胞的研究表明，白藜芦醇，一种天然的多酚，减少雄激素production.Objective：这项研究的目的是评估内分泌和代谢的影响白藜芦醇对PCOS.Design和设置：这是一个随机（1：1）双盲，安慰剂对照试验，评价白藜芦醇的影响超过3个月的一个学术hospital.Patients和其他参与者：与PCOS的主题被确定根据鹿特丹标准。34例受试者入组，30例受试者完成试验。干预：白藜芦醇（1，500 mg p.o.）主要结果测量：主要结果是血清总T的变化。结果：白藜芦醇治疗导致总T显著降低23.1%（P = 0.01）。同时，白藜芦醇诱导硫酸脱氢表雄酮降低22.2%（P =.01），空腹胰岛素水平降低31.8%（P =.007），胰岛素敏感性指数（Matsuda和DeFronzo）增加66.3%（P =.04）。促性腺激素水平，血脂以及炎症和内皮功能的标志物没有显着altered.Conclusions：白藜芦醇显着降低卵巢和肾上腺雄激素。这种作用可能至少部分与胰岛素敏感性的改善和胰岛素水平的下降有关。
Context: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting women of reproductive age. Hyperandrogenism is the central feature of PCOS. Studies on isolated ovarian theca-interstitial cells suggest that resveratrol, a natural polyphenol, reduces androgen production.Objective: This study was designed to evaluate endocrine and metabolic effects of resveratrol on PCOS.Design and Setting: This was a randomized (1:1) double-blind, placebo-controlled trial that evaluated the effects of resveratrol over a period of 3 months in an academic hospital.Patients and Other Participants: Subjects with PCOS were identified according to the Rotterdam criteria. Thirty-four subjects were enrolled and 30 subjects completed the trial. Evaluations were performed at baseline and repeated after 3 months of treatment.Intervention: Resveratrol (1,500 mg p.o.) or placebo were administered daily.Main Outcome Measure: Primary outcome was the change in the serum total T.Results: Resveratrol treatment led to a significant decrease of total T by 23.1% (P =.01). In parallel, resveratrol induced a 22.2% decrease of dehydroepiandrosterone sulfate (P =.01), a decrease of fasting insulin level by 31.8% (P =.007) and an increase of the Insulin Sensitivity Index (Matsuda and DeFronzo) by 66.3% (P =.04). Levels of gonadotropins, the lipid profile as well as markers of inflammation and endothelial function were not significantly altered.Conclusions: Resveratrol significantly reduced ovarian and adrenal androgens. This effect may be, at least in part, related to an improvement of insulin sensitivity and a decline of insulin level.