Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease.
Plasma leptin and insulin-like growth factor I levels during acute exacerbations of chronic obstructive pulmonary disease.
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DOI：
10.1186/1471-2466-9-11
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发表时间：
2009-04-05
影响因子：
3.1
通讯作者：
Bakakos P
中科院分区：
文献类型：
--
作者：
Kythreotis P;Kokkini A;Avgeropoulou S;Hadjioannou A;Anastasakou E;Rasidakis A;Bakakos P
最近的研究为瘦素和肿瘤坏死因子-α (TNF-α) 之间的联系提供了证据。胰岛素样生长因子 I (IGF-I) 介导生长激素 (GH) 的代谢作用。据信 GH 轴在慢性阻塞性肺疾病 (COPD) 中受到抑制。本研究的目的是查明慢性阻塞性肺病急性加重后血浆瘦素和胰岛素样生长因子 I (IGF-I) 水平是否发生变化，以及这些变化是否与全身炎症有关。我们测量了 52 名 COPD 急性加重患者入院时（第 1 天）和两周后（第 15 天）的血清瘦素、IGF-I、TNF-α、白细胞介素 1β (IL-1β)、白细胞介素 6 (IL-6) 和白细胞介素 8 (IL-8) 水平。 25 名年龄匹配的健康受试者作为对照。 COPD 患者也分为两个亚组（29 名慢性支气管炎患者和 23 名肺气肿患者）。采用放射免疫法测定血清瘦素、IGF-I，采用ELISA法测定TNF-α、IL-1β、IL-6、IL-8。第一天，COPD 患者的血清瘦素水平显着高于健康对照，血清 IGF-I 水平显着低于健康对照（p < 0.001）。第 1 天，瘦素和 TNF-α 之间观察到正相关（r = 0.620，p < 0.001）。与慢性支气管炎患者相比，肺气肿患者在第 1 天和第 15 天的 IGF-I 水平显着降低（分别为 p = 0.003 和 p < 0.001）。 COPD 急性加重期间，循环瘦素水平不适当地升高，同时 IGF-I 水平降低。与慢性支气管炎相比，肺气肿患者在病情恶化时和两周后的循环 IGF-I 水平均较低。
Recent studies have provided evidence for a link between leptin and tumor necrosis factor-alpha (TNF-α). Insulin-like growth factor I (IGF-I) mediates the metabolic effects of growth hormone (GH). The GH axis is believed to be suppressed in chronic obstructive pulmonary disease (COPD). The aim of this study is to find out whether acute exacerbations of COPD are followed by changes in plasma leptin and insulin-like growth factor I (IGF-I) levels and furthermore, whether these changes are related to systemic inflammation. We measured serum leptin, IGF-I, TNF-α, interleukin 1β (IL-1β), interleukin 6 (IL-6) and interleukin 8 (IL-8) levels in 52 COPD patients with acute exacerbation on admission to hospital (Day 1) and two weeks later (Day 15). 25 healthy age-matched subjects served as controls. COPD patients were also divided into two subgroups (29 with chronic bronchitis and 23 with emphysema). Serum leptin and IGF-I were measured by radioimmunoassay and TNF-α, IL-1β, IL-6 and IL-8 were measured by ELISA. Serum leptin levels were significantly higher and serum IGF-I levels significantly lower in COPD patients on Day 1 than in healthy controls (p < 0.001). A positive correlation was observed between leptin and TNF-α on Day 1 (r = 0.620, p < 0.001). Emphysematous patients had significantly lower IGF-I levels compared to those with chronic bronchitis both on Day 1 and Day 15 (p = 0.003 and p < 0.001 respectively). Inappropriately increased circulating leptin levels along with decreased IGF-I levels occured during acute exacerbations of COPD. Compared to chronic bronchitis, patients with emphysema had lower circulating IGF-I levels both at the onset of the exacerbation and two weeks later.