Factors associated with the development of chorioretinal atrophy around choroidal neovascularization in pathologic myopia
Factors associated with the development of chorioretinal atrophy around choroidal neovascularization in pathologic myopia
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DOI：
10.1007/s00417-003-0803-9
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发表时间：
2004-02-01
影响因子：
2.7
通讯作者：
Mochizuki, M
中科院分区：
文献类型：
--
作者：
Kojima, A;Ohno-Matsui, K;Mochizuki, M
目的。目的：探讨高度近视患者脉络膜视网膜萎缩发展的影响因素。脉络膜视网膜萎缩是近视性脉络膜新生血管(CNV)长期视力下降的主要原因。方法：研究方法。对65例(81只眼)近视性CNV进行了回顾性研究。用多元线性回归分析患者年龄、屈光度、眼轴长度、CNV发病时视力、CNV大小、近视性视网膜病变程度对发病3年以上的脉络膜视网膜萎缩程度的影响。结果。81只眼中77只眼(95.1%)在随访期发生近视性CNV周围的脉络膜视网膜萎缩。多元线性回归分析显示，年龄是所有受试者发生脉络膜视网膜萎缩的最大影响因素。然而，当我们根据年龄将受试者分为两组时，在40岁以下的患者中，CNV的大小是唯一影响脉络膜视网膜萎缩的因素，而在40岁以上的患者中，年龄仍然是唯一的影响因素。结论。影响脉络膜视网膜萎缩发生的因素因患者年龄不同而异。局部因素，如CNV大小，决定了年轻患者发生脉络膜视网膜萎缩的倾向。系统性因素，如患者年龄，在年龄较大的受试者中发挥更大的作用。
Purpose. To examine the influencing factors on the development of chorioretinal atrophy, which is the main cause of long-term visual decrease in myopic choroidal neovascularization (CNV), in a large series of highly myopic patients. Methods. Sixty-five patients (81 eyes) with myopic CNV were studied retrospectively. The influence of the patient's age, refractive error, axial length, visual acuity at onset of CNV, size of CNV, and grade of myopic retinopathy on the extent of chorioretinal atrophy more than 3 years after CNV onset was investigated by means of multiple linear regression analysis. Results. Seventy-seven of 81 eyes (95.1%) developed chorioretinal atrophy around myopic CNV during the follow-up period. Multiple linear regression revealed that age was the most influencing factor for the development of chorioretinal atrophy in all the subjects. When we divided the subjects into two groups according to their age, however, CNV size was the only factor to influence the development of chorioretinal atrophy in the patients younger than 40 years, whereas age was still the only influencing factor in those older than 40 years. Conclusions. The factors influencing the development of chorioretinal atrophy differ according to patient age. Local factors, such as CNV size, determine the tendency to develop chorioretinal atrophy in young patients. Systemic factors, such as patient age, play a greater part in older subjects.