Causes of epilepsy: Contributions of the Rochester epidemiology project
Causes of epilepsy: Contributions of the Rochester epidemiology project
复制标题
DOI：
10.4065/71.6.570
复制
发表时间：
1996-06-01
影响因子：
8.9
通讯作者：
Hauser, WA
中科院分区：
文献类型：
--
作者：
Annegers, JF;Rocca, WA;Hauser, WA
本文综述了罗切斯特（明尼苏达州）流行病学项目和梅奥诊所在癫痫病因评估方面的贡献，记录了独特的基于人群的医疗记录链接资源的发展，并介绍了流行病学研究设计中用于评估癫痫病因的发生率和相关性的措施。历史队列设计最适合研究常见中枢神经系统损伤与癫痫发作之间的关系，病例对照研究最适合分析相对罕见的癫痫发作疾病。本文讨论了创伤性脑损伤、中枢神经系统感染、脑血管疾病、脑肿瘤、神经退行性疾病、发育障碍、围产期损伤和家族因素的病因学作用的主要发现。遗传因素在癫痫中的作用一直存在争议，可能是因为癫痫发作的原因很多，而且是发作性的，潜在的环境和遗传原因都将继续被评估。
The contributions of the Rochester (Minnesota) Epidemiology Project and Mayo Clinic studies in the evaluation of the causes of epilepsy are summarized, The development of the unique population-based medical records-linkage resource is chronicled, and the measures of occurrence and association used in epidemiologic study designs to assess the causes of epilepsy are presented, The historical cohort design is optimal for the study of the relationship between common central nervous system insults and seizures, and case-control studies are best used for analysis of relatively rare seizure disorders, The major findings about the etiologic roles of traumatic brain injuries, central nervous system infections, cerebrovascular disease, brain tumors, neurodegenerative diseases, developmental disabilities, perinatal insults, and familial factors are discussed, The role of genetic factors in epilepsy has been controversial, perhaps because of the numerous causes of seizures and their episodic nature, Both potential environmental and genetic causes will continue to be assessed.