COVID-19 associated thyroid dysfunction and other comorbidities and its management using phytochemical-based therapeutics: a natural way.
COVID-19 associated thyroid dysfunction and other comorbidities and its management using phytochemical-based therapeutics: a natural way.
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DOI：
10.1042/bsr20230293
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发表时间：
2023-07-26
影响因子：
4
通讯作者：
Mostafavi, Ebrahim
中科院分区：
文献类型：
--
作者：
Parihar, Arpana;Malviya, Shivani;Khan, Raju;Kaushik, Ajeet;Mostafavi, Ebrahim
目前严重急性呼吸综合征-2(SARS-CoV-2)介导的冠状病毒大流行(新冠肺炎)及其后新冠肺炎并发症严重影响着人类的生活。已经治愈新冠肺炎感染的患者现在正在经历新冠肺炎后相关的合并症，这增加了死亡率。SARS-CoV-2感染使肺部、肾脏、胃肠道和包括甲状腺在内的各种内分泌腺感到痛苦。包括OMICRON(B.1.1.529)及其血统在内的变种的出现严重威胁着世界。在不同的治疗方法中，以植物化学为基础的治疗方法不仅成本低，而且副作用小。最近，大量研究表明，各种植物化学物质对治疗新冠肺炎有疗效。此外，各种植物化学物质已被发现对治疗几种炎症性疾病有效，包括与甲状腺相关的异常。这种植物化学制剂的方法快速简便，这种草药制剂的原材料在全球范围内被批准用于治疗某些疾病。鉴于植物化学物质的优势，本文主要讨论与新冠肺炎相关的甲状腺功能障碍，以及关键植物化学物质在处理甲状腺异常和新冠肺炎术后并发症中的作用。此外，这篇综述揭示了新冠肺炎及其相关并发症影响人体器官功能的机制，以及植物化学物质如何帮助治疗甲状腺患者新冠肺炎后并发症的机制。考虑到植物化学物质作为一种更安全、更具成本效益的药物所提供的优势，它们可能被用于对抗与新冠肺炎相关的合并症。
The present severe acute respiratory syndrome-2 (SARS-CoV-2) mediated Coronavirus pandemic (COVID-19) and post-COVID-19 complications affect human life drastically. Patients who have been cured of COVID-19 infection are now experiencing post-COVID-19 associated comorbidities, which have increased mortality rates. The SARS-CoV-2 infection distresses the lungs, kidneys, gastrointestinal tract, and various endocrine glands, including the thyroid. The emergence of variants which includes Omicron (B.1.1.529) and its lineages threaten the world severely. Among different therapeutic approaches, phytochemical-based therapeutics are not only cost-effective but also have lesser side effects. Recently a plethora of studies have shown the therapeutic efficacy of various phytochemicals for the treatment of COVID-19. Besides this, various phytochemicals have been found efficacious in treating several inflammatory diseases, including thyroid-related anomalies. The method of the phytochemical formulation is quick and facile and the raw materials for such herbal preparations are approved worldwide for human use against certain disease conditions. Owing to the advantages of phytochemicals, this review primarily discusses the COVID-19-related thyroid dysfunction and the role of key phytochemicals to deal with thyroid anomaly and post-COVID-19 complications. Further, this review shed light on the mechanism via which COVID-19 and its related complication affect organ function of the body, along with the mechanistic insight into the way by which phytochemicals could help to cure post-COVID-19 complications in thyroid patients. Considering the advantages offered by phytochemicals as a safer and cost-effective medication they can be potentially used to combat COVID-19-associated comorbidities.