Eph-ephrin signaling in nervous system development.
Eph-ephrin signaling in nervous system development.
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DOI：
10.12688/f1000research.7417.1
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发表时间：
2016-01-01
期刊：
影响因子：
--
通讯作者：
Miko, Ilona J
中科院分区：
文献类型：
--
作者：
Cramer, Karina S;Miko, Ilona J
ephrin和Eph受体在神经系统发育的每一个阶段使细胞之间的接触介导的相互作用成为可能。尽管具有广泛的结合亲和力，但Eph蛋白促进了神经元迁移和轴突靶向的特异性。这篇综述的重点是最近的研究，证明这些蛋白质如何相互作用，并与其他信号通路，以指导多种发育过程的特异性。
Ephrins and Eph receptors enable contact-mediated interactions between cells at every stage of nervous system development. In spite of their broad binding affinities, Eph proteins facilitate specificity in neuronal migration and axon targeting. This review focuses on recent studies that demonstrate how these proteins interact with each other, and with other signaling pathways, to guide specificity in a diverse set of developmental processes.