Prevalence and Heritability of Compulsive Hoarding: A Twin Study
Prevalence and Heritability of Compulsive Hoarding: A Twin Study
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DOI：
10.1176/appi.ajp.2009.08121789
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发表时间：
2009-10-01
影响因子：
17.7
通讯作者：
Mataix-Cols, David
中科院分区：
文献类型：
--
作者：
Iervolino, Alessandra C.;Perroud, Nader;Mataix-Cols, David
目的：强迫性囤积症是一个严重的健康问题，对患者，他们的家庭，和整个社会。它似乎非常普遍，并在家族中遗传。然而，这种熟悉可能是由于遗传或环境因素。这项研究在大量双胞胎样本中调查了强迫性囤积症的患病率和遗传性。方法：共有5022对双胞胎完成了强迫性囤积的有效测量。严重囤积的流行程度是用经验推导的截止值来确定的。使用责任阈值模型估计强迫性囤积的遗传和环境影响，并采用最大似然单变量模型拟合分析将强迫性囤积的倾向性方差分解为可加性遗传和共享和非共享环境因素（仅限女性双胞胎；N=4,355）。结果：共有2.3%的双胞胎符合病例标准，其中男性双胞胎（4.1%）明显高于女性双胞胎（2.1%）。对女性双胞胎的模型拟合分析表明，遗传因素占强迫性囤积差异的大约50%，非共享环境因素和测量误差占另一半。结论：强迫性囤积症是高度普遍和可遗传的，至少在女性中，非共享环境因素也可能发挥重要作用。
Objective: Compulsive hoarding is a serious health problem for the sufferers, their families, and the community at large. It appears to be highly prevalent and to run in families. However, this familiality could be due to genetic or environmental factors. This study examined the prevalence and heritability of compulsive hoarding in a large sample of twins.Method: A total of 5,022 twins completed a validated measure of compulsive hoarding. The prevalence of severe hoarding was determined using empirically derived cutoffs. Genetic and environmental influences on compulsive hoarding were estimated using liability threshold models, and maximum-likelihood univariate model-fitting analyses were employed to decompose the variance in the liability to compulsive hoarding into additive genetic and shared and nonshared environmental factors ( female twins only; N=4,355).Results: A total of 2.3% of twins met criteria for caseness, with significantly higher rates observed for male (4.1%) than for female (2.1%) twins. Model-fitting analyses in female twins showed that genetic factors accounted for approximately 50% of the variance in compulsive hoarding, with nonshared environmental factors and measurement error accounting for the other half.Conclusions: Compulsive hoarding is highly prevalent and heritable, at least in women, with nonshared environmental factors also likely to play an important role.