An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis
An immunotherapeutic program for the treatment of nicotine addiction: Hapten design and synthesis
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DOI：
10.1021/jo001442w
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发表时间：
2001-06-15
影响因子：
3.6
通讯作者：
Janda, KD
中科院分区：
文献类型：
--
作者：
Isomura, S;Wirsching, P;Janda, KD
人们继续吸烟和使用烟草制品，尽管其危害性已得到公认。最重要的因素是尼古丁的成瘾性。对于尼古丁依赖的问题，没有非常有效的治疗方法。免疫疗法提供了传统方法的替代方案。一个全面的免疫药理学计划所需的化学。制备了具有高光学纯度的半抗原，用于生成对天然存在的（S）-尼古丁、（S）-和（R）-去甲尼古丁以及代谢产物（S）-可替宁具有特异性的抗体。报告了抗尼古丁抗体的初步数据。
People continue to smoke and use tobacco products despite well-established hazardous consequences. The most contributing factor is the addictive nature of nicotine. There is no highly effective treatment for the problem of nicotine dependence. Immunotherapy offers an alternative to conventional approaches. The chemistry necessary for a comprehensive immunopharmacological program is presented. Haptens for the generation of antibodies specific for naturally occurring (S)-nicotine, (S)- and (R)-nornicotine, and the metabolite (S)-cotinine were prepared with high optical purity. Preliminary data for antinicotine antibodies are reported.