MULTICYSTIC MESOTHELIOMA - AN ANALYSIS OF PATHOLOGIC FINDINGS AND BIOLOGIC BEHAVIOR IN 37 CASES
MULTICYSTIC MESOTHELIOMA - AN ANALYSIS OF PATHOLOGIC FINDINGS AND BIOLOGIC BEHAVIOR IN 37 CASES
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DOI：
10.1097/00000478-198810000-00001
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发表时间：
1988-10-01
影响因子：
5.6
通讯作者：
TAVASSOLI, FA
中科院分区：
文献类型：
--
作者：
WEISS, SW;TAVASSOLI, FA
我们报告 37 例多囊性间皮瘤的临床病理结果。这种肿瘤最常发生在年轻至中年女性中，主要影响盆腔腹膜，特别是尾部、子宫和直肠。它沿着浆膜生长，形成多个、半透明、充满液体的囊肿。有时，它表现为一个单独的或自由漂浮的物体。该肿瘤由嵌入脆弱的纤维血管基质中的间皮囊肿组成。间皮细胞可以是扁平的或立方形的。三分之一的病例发生间皮腺瘤样改变或鳞状化生。在相当大比例的病例中，间质显示出明显的炎症变化，使得很难识别潜在的肿瘤性质。 25名患者的随访信息显示，21名患者存活，2名患者死于肿瘤，2名患者死于其他原因。两名死于肿瘤的患者中，有一名是婴儿，其肿瘤已转变为传统间皮瘤；另一个是拒绝接受治疗的男子。诊断时肿瘤的范围并不能预测生存率。既往手术发生率低、既往没有腹部感染以及疾病相关死亡率的记录都支持这种病变的肿瘤性基础，而不是反应性基础。
We report the clinicopathologic findings of 37 cases of multicystic mesothelioma. The tumor, which occurs most frequently in young to middle-aged women, affects chiefly the pelvic peritoneum.sbd.particularly the cul de sac, uterus, and rectum. It grows along the serosa as multiple, translucent, fluid-filled cysts. Occasionally, it manifests as a solitary or free-floating mass. The tumor is made up of mesothelial-lined cysts embedded in a delicate fibrovascular stroma. The mesothelial cells may be flattened or cuboidal. Adenomatoid change or squamous metaplasia of the mesothelium occurs in one-third of cases. In a significant percentage of cases, the stroma shows marked inflammatory changes that make it difficult to recognize the underlying neoplastic nature. Follow-up information in 25 patients showed that 21 patients were alive, two had died of tumor, and two died of other causes. One of the two patients who died of their tumors was an infant whose tumor showed transition to conventional mesothelioma; the other was a man who had refused therapy. The extent of tumor at the time of diagnosis did not predict survival. The low incidence of previous surgery, the lack of prior abdominal infections, and the documentation of disease-related mortality all support a neoplastic, rather than a reactive, basis for this lesion.