Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy.
Targeting tumor-associated macrophages in hepatocellular carcinoma: biology, strategy, and immunotherapy.
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肝癌中靶向肿瘤相关巨噬细胞：生物学、策略和免疫治疗。
DOI：
10.1038/s41420-023-01356-7
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发表时间：
2023-02-15
影响因子：
7
通讯作者：
Li, Hangyu
中科院分区：
文献类型：
--
作者：
Zheng, Hongyu;Peng, Xueqiang;Yang, Shuo;Li, Xinyu;Huang, Mingyao;Wei, Shibo;Zhang, Sheng;He, Guangpeng;Liu, Jiaxing;Fan, Qing;Yang, Liang;Li, Hangyu
肝细胞癌是恶性程度最高的肿瘤之一，其特点是免疫抑制微环境顽固。肿瘤相关巨噬细胞(TAMs)作为肝细胞癌肿瘤微环境(TME)的主要成员之一，在其发生发展过程中发挥着重要作用，包括刺激血管生成、增强免疫抑制、促进耐药和肿瘤转移等。本文综述了TAMs的起源、表型异质性及其在肝细胞癌发生发展中的潜在作用，并讨论了可用于靶向TAMs的各种辅助治疗策略。此外，我们还重点介绍了以免疫治疗为基础的TAMs的不同治疗模式，包括小分子抑制剂、免疫检查点抑制剂、抗体、肿瘤疫苗、过继细胞免疫治疗和纳米载体药物输送，以探索新的联合治疗方法，为临床改善肝癌患者的预后和生活质量提供可行的治疗方案。
Hepatocellular carcinoma (HCC), one of the most malignant tumors, is characterized by its stubborn immunosuppressive microenvironment. As one of the main members of the tumor microenvironment (TME) of HCC, tumor-associated macrophages (TAMs) play a critical role in its occurrence and development, including stimulating angiogenesis, enhancing immunosuppression, and promoting the drug resistance and cancer metastasis. This review describes the origin as well as phenotypic heterogeneity of TAMs and their potential effects on the occurrence and development of HCC and also discusses about various adjuvant therapy based strategies that can be used for targeting TAMs. In addition, we have highlighted different treatment modalities for TAMs based on immunotherapy, including small molecular inhibitors, immune checkpoint inhibitors, antibodies, tumor vaccines, adoptive cellular immunotherapy, and nanocarriers for drug delivery, to explore novel combination therapies and provide feasible therapeutic options for clinically improving the prognosis and quality of life of HCC patients.
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microRNA-26a 通过 PI3K/Akt 通路下调巨噬细胞集落刺激因子表达，从而抑制肝细胞癌中巨噬细胞的募集
影响因子：
28.5
作者：
Chai ZT;Zhu XD;Ao JY;Wang WQ;Gao DM;Kong J;Zhang N;Zhang YY;Ye BG;Ma DN;Cai H;Sun HC
通讯作者：
Sun HC
影响因子：
21.3
作者：
Costa-Silva B;Aiello NM;Ocean AJ;Singh S;Zhang H;Thakur BK;Becker A;Hoshino A;Mark MT;Molina H;Xiang J;Zhang T;Theilen TM;García-Santos G;Williams C;Ararso Y;Huang Y;Rodrigues G;Shen TL;Labori KJ;Lothe IM;Kure EH;Hernandez J;Doussot A;Ebbesen SH;Grandgenett PM;Hollingsworth MA;Jain M;Mallya K;Batra SK;Jarnagin WR;Schwartz RE;Matei I;Peinado H;Stanger BZ;Bromberg J;Lyden D
通讯作者：
Lyden D
DOI：
10.1002/advs.202004574
发表时间：
2021-05
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Bolli E;Scherger M;Arnouk SM;Pombo Antunes AR;Straßburger D;Urschbach M;Stickdorn J;De Vlaminck K;Movahedi K;Räder HJ;Hernot S;Besenius P;Van Ginderachter JA;Nuhn L
通讯作者：
Nuhn L
影响因子：
10.9
作者：
Cannarile MA;Weisser M;Jacob W;Jegg AM;Ries CH;Rüttinger D
通讯作者：
Rüttinger D
一种基于旁观者细胞的 GM-CSF 分泌疫苗与低剂量环磷酰胺协同作用，可呈现针对小鼠肝细胞癌的治疗性免疫反应
影响因子：
24.1
作者：
Chen, Chen;Hou, Jiajie;Sun, Beicheng
通讯作者：
Sun, Beicheng