Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss
Schisandrin B Inhibits Osteoclastogenesis and Protects Against Ovariectomy-Induced Bone Loss
复制标题
五味子 B 抑制破骨细胞生成并防止卵巢切除引起的骨质流失
DOI：
10.3389/fphar.2020.01175
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发表时间：
2020-07-31
影响因子：
5.6
通讯作者：
Li, Feng
中科院分区：
文献类型：
--
作者：
Wang, Jia;Fang, Zhong;Li, Feng
骨质疏松症是一种全身性骨骼疾病，在世界范围内高度流行，被认为与破骨细胞介导的过度骨吸收有关。破骨细胞分化的特征在于炎症相关通路的激活和活性氧的产生。五味子醇甲B具有较强的抗炎和抗氧化活性，因此推测五味子醇甲B可能是治疗骨质疏松症的潜在药物。在本研究中，我们发现，破骨细胞的形成和“功能显着抑制的五味子乙素B。与体外结果一致，用五味子乙素B治疗可减轻卵巢切除术诱导的小鼠骨丢失。此外，五味子乙素B还能显著抑制丝裂原活化蛋白激酶（MAPK）和核因子-κB（NF-κB）通路的激活，并通过激活核因子E2 p45相关因子2（Nrf 2）信号通路清除ROS。综上所述，我们的研究表明，五味子乙素B是一种有效的方法来治疗骨质疏松症和其他破骨细胞相关疾病。
Osteoporosis is a systemic skeletal disease which is highly prevalent worldwide and considered to be associated with excessive bone resorption mediated by osteoclast. Osteoclast differentiation is featured by the activation of inflammation-related pathways and the generation of reactive oxygen species. Schisandrin B is a bioactive compound with strong antiinflammation and antioxidative properties, we thus speculated that Schisandrin B might serve as a potential candidate for osteoporosis. In the present study, we found that the formation and` function of osteoclasts were dramatically suppressed by Schisandrin B. And consistent with the in vitro results, treatment with Schisandrin B attenuated ovariectomy-induced bone loss in mice. Moreover, Schisandrin B notably inhibited the activation of mitogen activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) pathways and scavenged ROS by activating nuclear factor E2 p45-related factor 2 (Nrf2) signaling. In conclusion, our study indicates that Schisandrin B is an effective approach to treat osteoporosis and other osteoclast-related diseases.