NADPH-DIAPHORASE NITRIC-OXIDE SYNTHASE CONTAINING NEURONS IN NORMAL AND PARKINSONS-DISEASE PUTAMEN
NADPH-DIAPHORASE NITRIC-OXIDE SYNTHASE CONTAINING NEURONS IN NORMAL AND PARKINSONS-DISEASE PUTAMEN
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DOI：
10.1007/bf02260966
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
RIEDERER, P
中科院分区：
文献类型：
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作者：
BOCKELMANN, R;WOLF, G;RIEDERER, P
一氧化氮（NO）被认为参与神经退行性过程。关于帕金森病（PD），它仍然有待澄清，如果NO有助于纹状体的病理改变。本研究评估死后壳核的PD患者和对照组的分布模式的NO合酶含神经元，使用NADPH-黄递酶技术。阳性染色神经元的比率和细胞总数（对照：1，120 +/-69/mm（2），n = 5; PD：575 +/-164 mm（2），n = 5）显示对照和PD患者之间的显著差异。我们的研究结果有理由得出这样的结论，NADPH-黄递酶阳性结构可能具有致病的重要性，在PD壳核的退行性过程。
Nitric oxide (NO) is thought to be involved in neurodegenerative processes. Concerning Parkinson's disease (PD) it remains to be elucidated, if NO contributes to pathological alterations in the striatum. The present study evaluates the post-mortem putamen of PD patients and control subjects for distribution patterns of NO-synthase containing neurons, using the NADPH-diaphorase technique. The ratio of positively stained neurons and the total number of cells (control: 1,120 +/- 69 per mm(2), n = 5; PD: 575 +/- 164 mm(2), n = 5) shows striking differences between controls and PD patients. Our findings give reason to conclude that NADPH-diaphorase positive structures may have pathogenetic importance in degenerative processes in PD putamen.