Transcriptional Regulation by Trithorax-Group Proteins
Transcriptional Regulation by Trithorax-Group Proteins
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DOI：
10.1101/cshperspect.a019349
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发表时间：
2014-10-01
影响因子：
7.2
通讯作者：
Tamkun, John W.
中科院分区：
文献类型：
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作者：
Kingston, Robert E.;Tamkun, John W.
在突变筛选中鉴定了三胸基因组（trxG），该筛选检查了发育表型和Polycomb突变表型的抑制。这些基因的蛋白质产物主要参与基因激活，尽管有些也可能具有抑制作用。这些蛋白质没有核心功能。一些以ATP依赖的方式在基因组上移动核小体，一些共价修饰组蛋白，如甲基化组蛋白H3的赖氨酸4，还有一些直接与转录机制相互作用，或者是该机制的一部分。有趣的是考虑为什么这些功能相关蛋白质大家族的特定成员具有强烈的发育表型。
The trithorax group of genes (trxG) was identified in mutational screens that examined developmental phenotypes and suppression of Polycomb mutant phenotypes. The protein products of these genes are primarily involved in gene activation, although some can also have repressive effects. There is no central function for these proteins. Some move nucleosomes about on the genome in an ATP-dependent manner, some covalently modify histones such as methylating lysine 4 of histone H3, and some directly interact with the transcription machinery or are a part of that machinery. It is interesting to consider why these specific members of large families of functionally related proteins have strong developmental phenotypes.