The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models.
The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models.
复制标题
DOI：
10.1016/j.jcmgh.2017.01.013
复制
发表时间：
2017-05
影响因子：
7.2
通讯作者：
Wang TC
中科院分区：
文献类型：
--
作者：
Hayakawa Y;Fox JG;Wang TC
消化道肿瘤的细胞起源一直是癌症领域的一个长期问题。小鼠模型已经在大多数器官系统中鉴定出长寿的干细胞，包括腔胃肠道，并且许多研究已经指出组织驻留干细胞是癌症的主要细胞来源。在胃癌发生过程中，慢性炎症诱导长寿干细胞的遗传和表观遗传改变，沿着干细胞小生境的扩大，最终导致浸润性癌。胃体和胃窦有不同的干细胞和干细胞小生境，表明在这两个部位对癌症起始的不同调节。在这篇简短的综述中，我们讨论了最近的实验模型和人体研究，这为胃癌的发病机制提供了重要的见解。
The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer.