Molecular Medicine
Molecular Medicine
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DOI：
10.1038/bjc.1986.27
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发表时间：
1986-01
影响因子：
8.8
通讯作者：
P.F.R. Little
中科院分区：
文献类型：
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作者：
P.F.R. Little
这个新系列的编辑艾伦·马尔科姆在他的介绍中勇敢地声称“医疗保健的未来改进将在很大程度上依赖于我们对（疾病）过程的分子基础的理解”。我并不反对这种说法，但在短期内，分子方法无法描述整个生物体更复杂的行为，这引发了对该方法及其基本还原论哲学的大量批评。分子医学的成功或失败将取决于它在广泛的临床环境中证明分子分析的真正有用性的程度。这是一个可以在系列中涵盖的有用领域吗？毫无疑问是的，作为临床医生和分子科学家之间双向交流观点的论坛。专业期刊及其偶尔发表的评论文章都无法充分发挥这一作用。它实现了这些目标吗？这里的答案是，它可能过于保守，过于强调临床活动，与分子医学（而不是医学）主题没有直接关系。这部分是由于最初选择的主题，部分是由于一些作者的特殊兴趣。我想补充一点，所有的文章都是高水平的，制作精良，并且非常有趣。所涵盖的主题相当不同，理论上应该通过分子分析的线索联系起来。关于染色体重排和癌症、胶原蛋白疾病以及核磁共振在临床成像中的应用的文章确实如此。尽管许多分子生物学应用于 a-1 抗蛋白酶抑制剂，并且对霍乱和相关毒素进行了非常清晰的回顾，但有关肺气肿的分子文章略少。然而，关于甲胎蛋白和肾素血管紧张素系统的文章并没有真正利用分子分析和极其可读的、尽管黯淡和令人沮丧的评论。
The editor of this new series, Alan Malcolm, bravely claims in his introduction that'future improvements in health care are going to rely heavily on our understanding of the molecular basis of the (disease) process'. I do not disagree with this statement but in the short-term the inability of the molecular approach to describe the more complex behaviour of whole organisms has prompted numerous sterile critiques of the method and its underlying reductionist philosophy. The success or failure of Molecular Medicine will be judged by the degree it demonstrates the real usefulness of molecular analysis in a wide clinical setting. Is it a useful area to cover in a series? Unequivocally yes, as a forum for thetwo-way exchange of perspective between clinician and molecular scientist. This is a role that is not adequately filled by either the specialist journals nor their occasional review articles. Does it achieve these aims? The answer here is that it has probably been pitched too conservatively with too much emphasis on clinical activity with no direct relationship to the topic of Molecular Medicine as opposed to Medicine. This is, in part, due to the initial choice of topics covered and in part due to the particular interests of some of the authors. I would add that all the articles are of high standard, well produced and of considerable interest.The topics covered are fairly disparate and should, in theory, be connected by the thread of molecular analysis. This is certainly true of articles on chromosome rearrangements and cancer, collagen disorders and the use of NMR in clinical imaging. Slightly less molecular are articles on pulmonary emphysema, although much molecular biology is applied to the a-1 antiprotease inhibitor, and a very clear review of cholera and related toxins. However, articles on alphafetoprotein and the renin angiotensin system do not really exploit molecular analysis and an extremely readable, albeit bleak and depressing review of the