Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers.
Preclinical Advances with Multiphoton Microscopy in Live Imaging of Skin Cancers.
复制标题
在皮肤癌的实时成像中，多光子显微镜的临床前进展。
DOI：
10.1016/j.jid.2016.08.033
复制
发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Greco V
中科院分区：
文献类型：
--
作者：
Sun TY;Haberman AM;Greco V
传统的静态分析在历史上一直是皮肤癌研究的基础和首选工具。在过去的几年中，使用多光子显微镜的肿瘤体内成像已经成为一种强大的临床前工具，可以揭示从肿瘤发展的最早时刻到转移的最后步骤的详细细胞行为。多光子显微镜允许以相对较小的光毒性穿透深层组织，使其成为长期观察肿瘤演变的有效工具。这篇综述强调了最近使用多光子显微镜获得的一些临床前见解，并提出了未来的进展，可以增强其揭示皮肤肿瘤生物学奥秘的能力。
Conventional, static analyses have historically been the bedrock and tool of choice for the study of skin cancers. Over the past several years, in vivo imaging of tumors using multiphoton microscopy has emerged as a powerful pre-clinical tool in revealing detailed cellular behaviors from the earliest moments of tumor development to the final steps of metastasis. Multiphoton microscopy allows for deep tissue penetration with relatively minor phototoxicity, rendering it an effective tool for the long-term observation of tumor evolution. This review highlights some of the recent preclinical insights gained using multiphoton microscopy, and suggests future advancements that could enhance its power in revealing the mysteries of skin tumor biology.