ACRP30, a new hormone controlling fat and glucose metabolism
ACRP30, a new hormone controlling fat and glucose metabolism
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DOI：
10.1016/s0014-2999(02)01430-9
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发表时间：
2002-04-12
影响因子：
5
通讯作者：
Fruebis, J
中科院分区：
文献类型：
--
作者：
Tsao, TS;Lodish, HF;Fruebis, J
脂肪细胞补体相关蛋白30（ACRP 30）是一种分泌型血清蛋白，仅在分化的脂肪细胞中表达。最近的研究表明，它的表达和血清水平降低，在人类和动物肥胖和胰岛素抵抗。代谢研究已经证明ACRP 30在调节葡萄糖和脂质稳态中的作用。本文就ACRP 30的生物化学及其生理功能的研究进展作一综述。我们还将讨论与未来研究方向相关的问题。(C)2002 Elsevier Science B.V.保留所有权利。
Adipocyte complement-related protein of 30 kDa (ACRP30) is a secreted serum protein expressed exclusively in differentiated adipocytes. Recent studies have indicated that its expression and serum levels are reduced in humans and animals with obesity and insulin resistance. Metabolic studies have demonstrated a role for ACRP30 in the regulation of glucose and lipid homeostasis. This review will describe the current literature on the biochemistry of ACRP30 and its physiological functions. We will also discuss issues that are relevant to the directions of future research. (C) 2002 Elsevier Science B.V. All rights reserved.