Effects of age on dopamine D2 receptor availability in striatal subdivisions: A high-resolution positron emission tomography study
Effects of age on dopamine D2 receptor availability in striatal subdivisions: A high-resolution positron emission tomography study
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DOI：
10.1016/j.euroneuro.2011.03.009
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发表时间：
2011-12-01
影响因子：
5.6
通讯作者：
Cho, Zang-Hee
中科院分区：
文献类型：
--
作者：
Kim, Jong-Hoon;Son, Young-Don;Cho, Zang-Hee
本研究的目的是使用[C-11]雷氯必利的高分辨率正电子发射断层扫描（PET）检查年轻和中年健康受试者纹状体分区中年龄与多巴胺D-2受体可用性之间的关系，以更好地表征纹状体D-2受体可用性与年龄相关的下降的性质。24名健康志愿者完成了3特斯拉磁共振成像和高分辨率[C-11]雷氯必利PET扫描。使用线性和指数模型的分析表明，年龄有一个显着的负相关性与D-2受体的可用性在连合后壳核（postPU）和D-2受体结合在postPU下降显着随着年龄的增长比在腹侧纹状体，表明次区域差异与年龄相关的变化D-2受体结合。属于感觉运动纹状体的postPU可能特别容易受到年轻和中年受试者年龄的影响。(C)2011 Elsevier B.V.和ECNP。All rights reserved.
The purpose of the present study was to examine the relationship between age and dopamine D-2 receptor availability in striatal subdivisions of young and middle-aged healthy subjects using high-resolution positron emission tomography (PET) with [C-11]raclopride to better characterize the nature of age-related decrements in striatal D-2 receptor availability. Twenty-four healthy volunteers completed 3-Tesla magnetic resonance imaging and high-resolution [C-11]raclopride PET scans. The analyses using linear and exponential models revealed that age had a significant negative correlation with D-2 receptor availability in the post-commissural putamen (postPU) and that D-2 receptor binding in the postPU decreased significantly more with age than in the ventral striatum, suggesting subregional differences in age-related changes in D-2 receptor binding. The postPU, which belongs to the sensorimotor striatum, may be particularly vulnerable to the effects of age in young and middle-aged subjects. (C) 2011 Elsevier B.V. and ECNP. All rights reserved.