Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride
Plasma levels and symptom complaints in patients maintained on daily dosage of methadone hydrochloride
复制标题
维持每日剂量盐酸美沙酮的患者的血浆水平和症状主诉
DOI：
10.1002/cpt1975176636
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发表时间：
1975
影响因子：
6.7
通讯作者：
A. Goldstein
中科院分区：
文献类型：
--
作者：
W. H. Horns;Madeline Rado;A. Goldstein
血浆美沙酮水平，症状的投诉，并非法使用阿片类药物的尿液检查，每周随访17例美沙酮维持计划。在给定剂量下，患者之间的血浆水平存在很大差异，这意味着美沙酮代谢率存在很大差异。尽管每天的剂量几乎不变，血浆美沙酮水平波动很大，从一周到一周，从一天到一天的个别患者。除了极少数例外，血浆美沙酮水平和症状投诉之间或血浆美沙酮水平的每周变化和症状投诉的变化之间没有关系。除了可能确定偶尔的患者与异常低的血浆美沙酮水平，美沙酮水平的测定是不太可能在美沙酮计划的实用价值。
Plasma methadone levels, symptom complaints, and urine tests for illicit opiate use were followed weekly in 17 patients on a methadone maintenance program. There were very large differences between patients in the plasma level established at a given dosage, implying large differences in the rate of methadone metabolism. Despite virtually constant daily dosage, the plasma methadone levels fluctuated greatly from week to week and from day to day in individual patients. With rare exceptions there was no relationship between plasma methadone level and symptom complaints or between weekly changes in plasma methadone level and changes in symptom complaints. Except possibly to identify the occasional patient with unusually low plasma methadone levels, the determination of methadone levels is not likely to be of practical value in methadone programs.