One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water
One-year follow-up of perfluorinated compounds in plasma of German residents from Arnsberg formerly exposed to PFOA-contaminated drinking water
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DOI：
10.1016/j.ijheh.2009.04.003
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发表时间：
2009-09-01
影响因子：
6
通讯作者：
Wilhelm, Michael
中科院分区：
文献类型：
--
作者：
Hoelzer, Juergen;Goeen, Thomas;Wilhelm, Michael
在德国索尔兰地区的阿恩斯贝格，40000名居民接触到全氟辛烷磺酸污染的饮用水(500-640ng全氟辛烷磺酸/1；2006年5月)。2006年7月，饮用水中全氟辛酸浓度通过自来水厂的活性碳过滤显著降低，大部分低于检测下限(10 ng/L)。2006年秋季进行的第一项人体生物监测研究显示，居住在Arnsberg的居民血浆中的全氟辛烷磺酸浓度是参照组的4.5-8.3倍。第一次调查一年后，所有参与者(2006年：164名母亲、90名儿童、101名男性)都被邀请参加后续研究。这项研究的目的是确定血浆中全氟辛烷磺酸浓度的下降。288人(81%)进入统计分析。在一年内，Arnsberg居民血浆中全氟辛酸的几何平均浓度从儿童的22.1ug/L下降到17.4mUg/L，母亲从23.4下降到18.8mg/L，男性从25.3下降到23.4mg/L。每个人的全氟辛烷磺酸浓度的平均(几何平均值)变化约为10%(男性)、17%(母亲)和20%(儿童)/年。观察到的全氟辛烷磺酸浓度的下降表明在人体内消除缓慢。在普通人群中的这一发现与在职业暴露工人中观察到的长消除半衰期的数据是一致的。(C)2009年爱思唯尔股份有限公司。版权所有。
In Arnsberg, Sauerland area Germany, 40000 residents were exposed to PFOA-contaminated drinking water (500-640 ng PFOA/1; May 2006). In July 2006, the PFOA-concentrations in drinking water were lowered significantly by activated charcoal filtering in the waterworks, mostly below the limit of detection (10 ng/l). A first human biomonitoring study performed in autumn 2006 revealed that PFOA-concentrations in blood plasma of residents living in Arnsberg were 4.5-8.3 times higher than in the reference groups. One year after the first survey, all participants (2006: 164 mothers, 90 children, 101 men) were invited to take part In a follow-up study. It was the aim of the study to determine the decline of the PFOA-concentrations in blood plasma. 288 persons (81%) were included in the statistical analysis. The (geometric) mean PFOA-concentrations in blood plasma of Arnsberg's residents decreased from 22.1 to 17.4 mu g/l in children, from 23.4 to 18.8 mu g/l in mothers and from 25.3 to 23.4 mu g/l in men within one year. The average (geometric mean) changes in each individual's PFOA-concentrations were approximately 10 (men), 17 (mothers) and 20 (children) percent/year. The observed decline in PFOA-concentrations indicates a slow elimination in humans. This finding in groups of the general population is in agreement with data on long elimination half-lives observed in occupationally exposed workers. (C) 2009 Elsevier GmbH. All rights reserved.