MEMORY IN MICE AS AFFECTED BY INTRACEREBRAL PUROMYCIN
MEMORY IN MICE AS AFFECTED BY INTRACEREBRAL PUROMYCIN
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DOI：
10.1126/science.141.3575.57
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发表时间：
1963-01-01
期刊：
影响因子：
56.9
通讯作者：
STELLAR, E
中科院分区：
文献类型：
--
作者：
FLEXNER, JB;FLEXNER, LB;STELLAR, E
抗生素嘌呤霉素脑内注射可导致小鼠回避辨别学习记忆丧失。双侧注射嘌呤霉素，累及大脑前额叶皮层和邻近的颞叶皮层，导致短期记忆丧失;长期记忆的持续丧失需要注射，此外，还需要注射大部分剩余的皮层。有效的记忆痕迹从颞海马区扩散到皮层的广泛区域似乎需要3到6天，这取决于个体动物。最近的逆转学习丢失，而长期的初始学习保留后，双边注射到颞区。
The antibiotic, puromycin, caused loss of memory of avoidance discrimination learning in mice when injected intracerebrally. Bilateral injections of puromycin involving the hippocampi and adjacent temporal cortices caused loss of short-term memory; consistent loss of longer-term memory required injections involving, in addition, most of the remaining cortices. Spread of the effective memory trace from the temporal-hippocampal areas to wide areas of the cortices appears to require 3 to 6 days, depending upon the individual animal. Recent reversal learning was lost while longer-term initial learning was retained after bilateral injections into the hippocampal-temporal areas.