Basal and ACTH-stimulated cortisol and aldosterone release from adrenocortical adenomas in vitro.
Basal and ACTH-stimulated cortisol and aldosterone release from adrenocortical adenomas in vitro.
复制标题
体外肾上腺皮质腺瘤中基础和 ACTH 刺激的皮质醇和醛固酮释放。
DOI：
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发表时间：
1991
期刊：
影响因子：
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通讯作者：
B. Hamberger
中科院分区：
文献类型：
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作者：
S. Gröndal;Lars Grimelius;Marja Thorén;B. Hamberger
在连续16例Conn综合征（n = 7）、库欣综合征（n = 5）或无类固醇分泌过多体征（n = 4）患者的肾上腺皮质腺瘤和肾上腺皮质切片中研究了基础和ACTH刺激的醛固酮和皮质醇释放。回顾临床资料并重复组织学检查。肾上腺皮质和所有肿瘤，除了一个（非功能亢进）分泌皮质醇。在13/15个肿瘤和所有皮质切片中加入ACTH后，皮质醇释放增加。所有患者的肾上腺皮质均分泌醛固酮，75%的组织标本中ACTH使醛固酮增加。醛固酮增多症患者的腺瘤表现出最高的基础醛固酮分泌。这种分泌进一步增加促肾上腺皮质激素。没有皮质类固醇过量迹象的患者的肿瘤也释放类固醇并对ACTH有反应。它的结论是，在体外研究的类固醇释放肾上腺皮质肿瘤有助于他们的诊断和功能评价。
Basal and ACTH-stimulated release of aldosterone and cortisol was studied in slices of adrenocortical adenomas and adrenal cortex from 16 consecutive patients with Conn's syndrome (n = 7), Cushing's syndrome (n = 5) or no signs of steroid hypersecretion (n = 4). Clinical data were reviewed and histologic examination was repeated. The adrenal cortex and all tumours but one (non-hyperfunctioning) secreted cortisol. Cortisol release increased after addition of ACTH in 13/15 tumours and all cortex slices. Aldosterone was secreted from the adrenal cortex in all patients and was increased by ACTH in 75% of the tissue specimens. Adenomas from patients with hyperaldosteronism showed the highest basal aldosterone secretion. This secretion was further increased by ACTH. Tumours from patients without signs of corticosteroid excess also released steroids and responded to ACTH. It is concluded that in vitro studies of steroids released from adrenocortical tumours contribute to their diagnostic and functional evaluation.