Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans
Quantitative measures of hair cell loss in CBA and C57BL/6 mice throughout their life spans
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DOI：
10.1121/1.418315
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发表时间：
1997-06-01
影响因子：
2.4
通讯作者：
Salvi, RJ
中科院分区：
文献类型：
--
作者：
Spongr, VP;Flood, DG;Salvi, RJ
CBA小鼠直到生命晚期才显示出很少的听力损失证据，而C57 BL/6品系在大约3-6个月大时开始出现严重和进行性的高频感音神经性听力损失。这些功能差异与年龄相关的毛细胞损失量的遗传差异有关;然而，感觉细胞损失的精确定量描述是不可用的。本研究提供了CBA和C57 BL/6小鼠在1、3、8、18和26月龄时内毛细胞（IHC）和外毛细胞（OHC）损失的平均值。CBA小鼠在18个月大之前几乎没有毛细胞损失的证据。在26月龄时，耳蜗顶部和底部的OHC损失分别约为65%和50%，IHC损失约为25%和35%。相比之下，C57 BL/6小鼠在3月龄时在耳蜗基部显示出约75%的OHC和55%的IHC损失。OHC和IHC损失随着年龄的增长而迅速增加，沿沿着从基部到顶端的梯度。到26个月大。在整个耳蜗中，超过80%的OHC缺失;然而，LHC的损失范围从耳蜗底部附近的100%到顶端的约20%。(C)1997年美国声学学会。
The CBA mouse shows little evidence of hearing loss until late in life, whereas the C57BL/6 strain develops a severe and progressive, high-frequency sensorineural hearing loss beginning around 3-6 months of age. These functional differences have been linked to genetic differences in the amount of hair cell loss as a function of age; however, a precise, quantitative description of the sensory cell loss is unavailable. The present study provides mean values of inner hair cell (IHC) and outer hair cell (OHC) loss for CBA and C57BL/6 mice at 1, 3, 8, 18, and 26 months of age. CBA mice showed little evidence of hair cell loss until 18 months of age. At 26 months of age, OHC losses in the apex and base of the cochlea were approximately 65% and 50%, respectively, and IHC losses were approximately 25% and 35%. By contrast, C57BL/6 mice showed approximately a 75% OHC and a 55% IHC loss in the base of the cochlea at 3 months of age. OHC and IHC losses increased rapidly with age along a base-to-apex gradient. By 26 months of age. more than 80% of the OHCs were missing throughout the entire cochlea; however, LHC losses ranged from 100% near the base of the cochlea to approximately 20% in the apex. (C) 1997 Acoustical Society of America.