IL-11 mediates the Radioresistance of Cervical Cancer Cells via the PI3K/Akt Signaling Pathway.
IL-11 mediates the Radioresistance of Cervical Cancer Cells via the PI3K/Akt Signaling Pathway.
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IL-11 通过 PI3K/Akt 信号通路介导宫颈癌细胞的放射抗性。
DOI：
10.7150/jca.56185
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发表时间：
2021
影响因子：
3.9
通讯作者：
Luo Z
中科院分区：
文献类型：
--
作者：
Sun R;Chen C;Deng X;Wang F;Song S;Cai Q;Wang J;Zhang T;Shi M;Ke Q;Luo Z
宫颈癌是女性生殖系统最常见的恶性肿瘤之一。放射抗性仍然是限制宫颈癌放射治疗疗效的一个重要因素。据报道，白细胞介素-11（IL-11）在各种类型的人类癌症中上调，并与临床分期和不良生存期相关。然而，IL-11在宫颈癌放射抵抗中的确切作用和机制尚未确定。在这项研究中，TCGA数据库显示，IL-11表达在宫颈癌组织中上调，并与宫颈癌患者的临床分期和不良预后相关。我们发现IL-11浓度在放射抗性宫颈癌细胞中显著上调。下调IL-11基因可降低Hela细胞克隆形成率，降低细胞活力，诱导G2/M期阻滞，促进细胞凋亡。相反，外源性IL-11可上调C33 A细胞的克隆形成存活率，增加细胞活力，抑制G2/M期阻滞和细胞凋亡。机制研究表明，IL-11赋予的辐射抗性归因于PI 3 K/Akt信号通路的激活。总之，我们的研究结果表明，IL-11可能参与放射抵抗，IL-11可能是一个有效的放射增敏靶点，用于宫颈癌治疗。
Cervical cancer is one of the most common malignant tumors in the female reproductive system. Radioresistance remains a significant factor that limits the efficacy of radiotherapy for cervical cancer. Interleukin‐11 (IL-11) has been reported to be upregulated in various types of human cancer and correlate with clinical stage and poor survival. However, the exact effects and mechanisms of IL-11 in the radioresistance of cervical cancer have not yet been defined. In this research, TCGA databases revealed that IL-11 expression was upregulated in cervical cancer tissues and was associated with clinical stages and poor prognosis in cervical cancer patients. We discovered that IL-11 concentration was significantly upregulated in radioresistant cervical cancer cells. Knocking down IL-11 in Hela cells could reduce clonogenic survival rate, decrease cell viability, induce G2/M phase block, and facilitate cell apoptosis. In contrast, Exogeneous IL-11 in C33A cells could upregulate clonogenic survival rate, increase cell viability, curb G2/M phase block, and cell apoptosis. Mechanistic investigations showed that radioresistance conferred by IL-11 was attributed to the activation of the PI3K/Akt signaling pathway. Altogether, our results demonstrate that IL-11 might be involved in radioresistance, and IL-11 may be a potent radiosensitization target for cervical cancer therapy.
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影响因子：
34.3
作者：
Arbyn, Marc;Weiderpass, Elisabete;Bray, Freddie
通讯作者：
Bray, Freddie
影响因子：
3.5
作者：
Petrocchi-Passeri, Pamela;Cero, Cheryl;Possenti, Roberta
通讯作者：
Possenti, Roberta
DOI：
10.12659/msm.893689
发表时间：
2015-05-05
期刊：
Medical science monitor : international medical journal of experimental and clinical research
影响因子：
--
作者：
Fu ZC;Wang FM;Cai JM
通讯作者：
Cai JM
影响因子：
9
作者：
Li Q;Wei X;Zhou ZW;Wang SN;Jin H;Chen KJ;Luo J;Westover KD;Wang JM;Wang D;Xu CX;Shan JL
通讯作者：
Shan JL
DOI：
10.1073/pnas.1319665110
发表时间：
2013-12-17
影响因子：
11.1
作者：
Louria-Hayon, Igal;Frelin, Catherine;Pawson, Tony
通讯作者：
Pawson, Tony