Performing the synthesis of a complex molecule on sequentially linked columns: Toward the development of a "synthesis machine"
Performing the synthesis of a complex molecule on sequentially linked columns: Toward the development of a "synthesis machine"
复制标题
DOI：
10.1021/ol050980y
复制
发表时间：
2005-07-07
期刊：
影响因子：
5.2
通讯作者：
Lectka, T
中科院分区：
文献类型：
--
作者：
France, S;Bernstein, D;Lectka, T
We describe the diastereoselective synthesis of a pharmaceutically active drug candidate via a column-based system. This methodology is complementary to classical solid-phase synthesis; individual columns are packed with resin-bound reagents and then linked in sequence and/or in parallel. In contrast to the traditional solid-phase approach, substrates are introduced in the mobile phase where they build up chemical complexity by percolating through the linked columns, ultimately eluting as the desired product.
