Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones.
Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones.
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DOI：
10.1080/10253890.2017.1336535
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发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Hammack SE
中科院分区：
文献类型：
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作者：
King SB;Toufexis DJ;Hammack SE
压力源暴露与许多精神病理的发病和严重程度有关，这些病理在女性中更为常见。此外，应激相关激素的表达和功能失调与这些疾病有关。有证据表明，PACAP在介导应激反应的应激回路中起关键作用，并且PACAP可能与性激素相互作用，导致应激相关疾病的性别差异。本文综述了应激生物学中的PACAP/PAC1系统，重点介绍了应激诱导的PACAP表达和信号通路改变在应激诱导的行为改变中的作用。此外，我们提供的最新数据表明，在包括PTSD在内的病理状态下，应激、PACAP和E/发情之间存在潜在的相互作用。这些研究表明，应激水平和循环E/发情可能对男性和女性的PACAPergic系统有不同的调节，从而影响焦虑样行为，这可能是人类精神疾病差异的一种机制。
Stressor exposure is associated with the onset and severity of many psychopathologies that are more common in women. Moreover, the maladaptive expression and function of stress-related hormones have been implicated in these disorders. Evidence suggest that PACAP has a critical role in the stress circuits mediating stress-responding, and PACAP may interact with sex hormones to contribute to sex differences in stress-related disease. In this review, we describe the PACAP/PAC1 system in stress biology focusing on the role of stress-induced alterations in PACAP expression and signaling in the development of stress-induced behavioral change. Additionally, we present more recent data suggesting potential interactions between stress, PACAP and E/estrus in pathological states, including PTSD. These studies suggest that the level of stress and circulating E/estrus may differentially regulate the PACAPergic system in males and females to influence anxiety-like behavior and may be one mechanism underlying the discrepancies in human psychiatric disorders.