Cutaneous Photosensitization by 8-Methoxypsoralen: Order-Dependent Synergism Between Radiation >380 nm and Broadband UVA
Cutaneous Photosensitization by 8-Methoxypsoralen: Order-Dependent Synergism Between Radiation >380 nm and Broadband UVA
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8-甲氧基补骨脂素的皮肤光敏化：>380 nm 辐射和宽带 UVA 之间的顺序依赖性协同作用
DOI：
10.1111/1523-1747.ep12261365
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发表时间：
1984
影响因子：
6.5
通讯作者：
J. Parrish
中科院分区：
文献类型：
--
作者：
R. Gange;P. Levins;R. Anderson;J. Parrish
用局部8-甲氧基补骨脂素（8-MOP）处理的人皮肤依次暴露于波长大于380 nm的辐射和宽带UVA（320-400 nm）。一个惊人的，顺序依赖性协同作用，相对于诱导皮肤光毒性测量延迟红斑。当在暴露于宽带UVA之前暴露于> 380 nm辐射时，效果是协同的。当顺序颠倒时，效果近似于累加。这种协同作用最好的解释是UVA诱导的转化为DNA交联的单加合物形成的事先暴露在> 380 nm。直接的含义是，DNA的交联由peptides是皮肤光毒性的主要重要事件，由于peptides。用8-MOP和> 380 nm的明显亚致敏剂量的辐射处理的皮肤对小剂量UVA保持协同致敏至少72 h，在对照部位中单独8-MOP的光敏化消失很长时间之后。这表明那些能够随后转化为DNA交联的磷脂-DNA单加合物的体内修复缓慢。
Human skin treated with topical 8-methoxypsoralen (8-MOP) was exposed sequentially to radiation at wavelengths longer than 380 nm and to broadband UVA (320–400 nm). A striking, order-dependent synergism with respect to the induction of cutaneous phototoxicity as measured by delayed erythema was present. When exposure to > 380 nm radiation preceded exposure to broadband UVA, the effect was synergistic. When the order was reversed, the effect was approximately additive. This synergism is best explained by UVA-induced conversion to DNA cross-links of the monoadducts formed by prior exposure at > 380 nm. The direct implication is that cross-linking of DNA by psoralen is the major important event in cutaneous phototoxicity due to psoralens. Skin treated with 8-MOP and markedly suberythemogenic doses of radiation > 380 nm remained synergistically sensitized to small doses of UVA for at least 72 h, long after photosensitization by 8-MOP alone had disappeared in control sites. This suggests slow in vivo repair of those psoralen-DNA monoadducts capable of being subsequently converted to DNA cross-links.
甲氧沙林和亚光毒性 UVA 照射引起的长时间皮肤光敏化。
DOI：
10.1111/1523-1747.ep12260043
发表时间：
1984
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Gange,RW;Levins,P;Murray,J;Anderson,RR;Parrish,JA
通讯作者：
Parrish,JA