Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.
Ionic currents that generate the spontaneous diastolic depolarization in individual cardiac pacemaker cells.
复制标题
在单个心脏起搏器细胞中产生自发舒张去极化的离子电流。
DOI：
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发表时间：
1985
影响因子：
11.1
通讯作者：
W. Giles
中科院分区：
文献类型：
--
作者：
E. Shibata;W. Giles
一种酶分散程序已经开发出来，以获得可行的，自发活动的单个心肌细胞的心脏起搏器组织：牛蛙（蛙catesbeiana）静脉窦。用单吸微电极技术记录了时间和电压依赖性的Ca ~（2+）和K ~+电流。结果表明，两个时间和电压依赖性电流相互作用，调制起搏电位的斜率。这些是：（i）延迟整流K+电流的衰减和（ii）激活的Ca 2+电流。此外，数据强烈表明，心脏起搏器组织没有内向整流背景K+电流。
An enzymatic dispersion procedure has been developed to obtain viable, spontaneously active single myocytes from cardiac pacemaker tissue: the bullfrog (Rana catesbeiana) sinus venosus. Recordings of time- and voltage-dependent Ca2+ and K+ currents have been made by using a single suction-microelectrode technique. The results show that two time- and voltage-dependent currents interact to modulate the slope of the pacemaker potential. These are: (i) the decay of a delayed rectifier K+ current and (ii) the activation of a Ca2+ current. In addition, the data strongly suggest that cardiac pacemaker tissue does not have an inwardly rectifying background K+ current.