SKIN-CANCER IN RENAL-TRANSPLANT RECIPIENTS IS ASSOCIATED WITH INCREASED CONCENTRATIONS OF 6-THIOGUANINE NUCLEOTIDE IN RED BLOOD-CELLS
SKIN-CANCER IN RENAL-TRANSPLANT RECIPIENTS IS ASSOCIATED WITH INCREASED CONCENTRATIONS OF 6-THIOGUANINE NUCLEOTIDE IN RED BLOOD-CELLS
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DOI：
10.1111/j.1365-2133.1985.tb02408.x
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发表时间：
1985-01-01
影响因子：
10.3
通讯作者：
MADDOCKS, JL
中科院分区：
文献类型：
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作者：
LENNARD, L;THOMAS, S;MADDOCKS, JL
108名肾移植受者(53名男性和55名女性)接受硫唑嘌呤(0.8-2.9 mg/kg/d)和强的松龙(10 mg/d)治疗，其中10名男性患有光化性角化病，其中5人患有皮肤光暴露区域的鳞状细胞癌。从移植到诊断这些皮损的时间从1.2年到9.0年(平均5.1年)。活性硫唑嘌呤代谢物6-硫鸟嘌呤核苷酸的浓度为120-425(平均276)pmol/8次。发生皮损的移植患者中有108个红细胞，平均每8次有54-203个红细胞。肾移植受者的匹配对照组中有108个红细胞。这一差异具有统计学意义(P=0.005)。在硫唑嘌呤用量、免疫抑制的临床表现、日光照射或感染人乳头瘤病毒方面，患者组与对照组之间差异无统计学意义。在这些患者中，红细胞中6-硫代鸟嘌呤核苷酸浓度升高与光化性角化病和恶性皮肤肿瘤的相关性支持化学致癌作为可能的原因。
Of 108 renal transplant recipients (53 men and 55 women) treated with azathioprine (0.8-2.9 mg/kg per day) and prednisolone (10 mg daily), 10 men had actinic keratoses, and five of these had squamous cell carcinoma, on light-exposed areas of skin. The time from transplantation to diagnosis of these skin lesions varied from 1.2 to 9.0 (mean 5.1) years. The concentration of the active azathioprine metabolite 6-thioguanine nucleotide was 120-425 (mean 276) pmol per 8 .times. 108 red blood cells in the transplant patients who developed skin lesions and 54-203 (mean 130) pmol per 8 .times. 108 red blood cells in a matched control group of renal transplant recipients. This difference was statistically significant (P = 0.005). There was no statistically significant difference between patients and controls in azathioprine dosage, clinical features of immunosuppression, sunlight exposure or infection with human papilloma virus. The association of raised 6-thioguanine nucleotide concentrations in red blood cells with actinic keratoses and malignant skin tumours in these patients supports chemical carcinogenesis as a possible cause.