Antibiotic synergy against biofilm-forming Pseudomonas aeruginosa
Antibiotic synergy against biofilm-forming Pseudomonas aeruginosa
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DOI：
10.1007/s12223-008-0008-z
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发表时间：
2008-01-01
影响因子：
2.6
通讯作者：
Votava, M.
中科院分区：
文献类型：
--
作者：
Cernohorska, L.;Votava, M.
8种抗生素(氨曲南、头孢他啶、头孢哌酮、头孢匹林、奈替米星、阿米卡星、氧氟沙星和环丙沙星)对20株野生型生物被膜铜绿假单胞菌具有单独和/或联合抗菌活性。这些菌株对生物被膜的敏感性较低；在10株菌株中，氨曲南和环丙沙星联合应用有协同抗菌作用。对β-内酰胺类和氨基糖苷类、β-内酰胺类和氟喹诺酮类、氨基糖苷类和氟喹诺酮类，以及单菌素和β-内酰胺类的菌株也有协同作用，尽管这些菌株对个别抗生素有耐药性。一种或多种抗生素组合对32.4%的分离株有协同或部分增效作用。
Eight antibiotics (aztreonam, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, ofloxacin and ciprofloxacin) exhibited antimicrobial activity individually and/or in combinations against 20 wildtype biofilm-forming strains of Pseudomonas aeruginosa. The strains were less susceptible in biofilm; in 10 strains antibiotic synergy was observed for the combination of aztreonam and ciprofloxacin. Synergy was also demonstrated in the case of beta-lactams and aminoglycosides, beta-lactams and fluoroquinolones, aminoglycosides and fluoroquinolones, and for monobactams and beta-lactams although the strains were resistant to the individual antibiotics. Synergism or partial synergism was found with one or more antibiotic combinations against 32.4 % of isolates.