Preprogramming Complex Hydrogel Responses using Enzymatic Reaction Networks
Preprogramming Complex Hydrogel Responses using Enzymatic Reaction Networks
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DOI：
10.1002/anie.201610875
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发表时间：
2017-02-06
影响因子：
16.6
通讯作者：
Huck, Wilhelm T. S.
中科院分区：
文献类型：
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作者：
Postma, Sjoerd G. J.;Vialshin, Ilia N.;Huck, Wilhelm T. S.
适应性物质的产生在很大程度上受到生物系统的启发。然而，设计由反应网络控制的复杂材料反应仍然具有挑战性，反应网络位于细胞复杂性的核心。进展缓慢的主要原因是缺乏将反应网络与材料相结合的总体战略。在这里，我们使用一种系统的方法来预先编程水凝胶对触发器的响应，在这种情况下是酶-胰蛋白酶，它激活嵌入水凝胶中的反应网络。对系统中所有动力学速率常数的充分表征使计算模型的构建成为可能，该模型根据触发器的输入浓度预测不同的水凝胶响应。模拟结果与实验结果吻合较好。我们的方法可以用来设计新的适应性材料，其性质受任意复杂的反应网络控制。
The creation of adaptive matter is heavily inspired by biological systems. However, it remains challenging to design complex material responses that are governed by reaction networks, which lie at the heart of cellular complexity. The main reason for this slow progress is the lack of a general strategy to integrate reaction networks with materials. Herein we use a systematic approach to preprogram the response of a hydrogel to a trigger, in this case the enzyme trypsin, which activates a reaction network embedded within the hydrogel. A full characterization of all the kinetic rate constants in the system enabled the construction of a computational model, which predicted different hydrogel responses depending on the input concentration of the trigger. The results of the simulation are in good agreement with experimental findings. Our methodology can be used to design new, adaptive materials of which the properties are governed by reaction networks of arbitrary complexity.