The ATR barrier to replication-born DNA damage.
The ATR barrier to replication-born DNA damage.
复制标题
DOI：
10.1016/j.dnarep.2010.09.012
复制
发表时间：
2010-12-10
期刊：
影响因子：
3.8
通讯作者：
Fernandez-Capetillo O
中科院分区：
文献类型：
--
作者：
López-Contreras AJ;Fernandez-Capetillo O
复制是有代价的。DNA在复制过程中发生的分子体操经常导致广泛的异常，这些异常仍然远未被理解。这些都是在统一的术语“复制应激”（RS）下汇集在一起的，它可能代表单链DNA（ssDNA）的大而未受保护的区域。除了RS之外，ssDNA的重组发生延伸也在切除的DNA双链断裂（DSB）处形成。这两种情况都集中在ssDNA中间体上，这是损伤情况的触发信号。在这两种情况下，细胞反应都是由基于磷酸化的信号级联反应协调的，该信号级联反应始于ATR（ATM和Rad3相关）激酶的激活。鉴于ATR是复制细胞所必需的，直到最近几年，对哺乳动物有机体ATR反应缺陷的后果的理解一直是有限的。我们在这里讨论这个话题，并回顾将ATR与衰老和癌症联系起来的发现。
Replication comes with a price. The molecular gymnastics that occur on DNA during its duplication frequently derive to a wide spectrum of abnormalities which are still far from understood. These are brought together under the unifying term “replicative stress” (RS) which likely stands for large and unprotected regions of single-stranded DNA (ssDNA). In addition to RS, recombinogenic stretches of ssDNA are also formed at resected DNA double strand breaks (DSB). Both situations converge on a ssDNA intermediate, which is the triggering signal for a damage situation. The cellular response in both cases is coordinated by a phosphorylation-based signaling cascade that starts with the activation of the ATR (ATM and Rad3-related) kinase. Given that ATR is essential for replicating cells, understanding the consequences of a defective ATR response for a mammalian organism has been limited until recent years. We here discuss on the topic and review the findings that connect ATR to ageing and cancer.
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DOI：
10.1083/jcb.200905059
发表时间：
2010-03-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Beck H;Nähse V;Larsen MS;Groth P;Clancy T;Lees M;Jørgensen M;Helleday T;Syljuåsen RG;Sørensen CS
通讯作者：
Sørensen CS
影响因子：
64.8
作者：
Bartkova, J;Horejsi, Z;Bartek, J
通讯作者：
Bartek, J
影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
通讯作者：
Gorgoulis, Vassilis G.
影响因子：
64.8
作者：
Di Micco, Raffaella;Fumagalli, Marzia;di Fagagna, Fabrizio d'Adda
通讯作者：
di Fagagna, Fabrizio d'Adda
影响因子：
16
作者：
Callen, Elsa;Jankovic, Mila;Wong, Nancy;Zha, Shan;Chen, Hua-Tang;Difilippantonio, Simone;Di Virgilio, Michela;Heidkamp, Gordon;Alt, Frederick W.;Nussenzweig, Andre;Nussenzweig, Michel
通讯作者：
Nussenzweig, Michel