Continuous monitoring and quantification of multiple parameters of daily physical activity in ambulatory Duchenne muscular dystrophy patients
Continuous monitoring and quantification of multiple parameters of daily physical activity in ambulatory Duchenne muscular dystrophy patients
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DOI：
10.1016/j.ejpn.2010.07.002
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发表时间：
2011-01-01
影响因子：
3.1
通讯作者：
Paraschiv-Ionescu, Anisoara
中科院分区：
文献类型：
--
作者：
Jeannet, Pierre-Yves;Aminian, Kamiar;Paraschiv-Ionescu, Anisoara
存在多种运动功能和力量评估工具用于评估神经肌肉疾病，但大多数工具并不能直接评估患者在家庭环境中日常身体活动的功能能力。在本研究中，我们的目的是评估：1) 在 5 名 DMD 患者的家庭环境中使用包含 3D 加速计和陀螺仪的非商业化监测仪进行两天身体活动监测的可行性和准确性，2) 是否可以在开始使用泼尼松龙之前和一个月后测量身体活动参数的差异。我们可靠地量化了坐、站、躺、行走的时间、步数、节奏、行走次数和持续时间，以及这些时间在一天中的分布情况。可能反映耐力的参数，例如步行发作的持续时间或持续超过 30 秒的连续两到三次步行发作，在泼尼松龙治疗后改善最大。据我们所知，这种对家庭环境中身体活动的详细确定程度以前在神经肌肉疾病中尚未有报道，并且一些报道的参数是临床试验中潜在的新结果测量。 (C) 2010 年欧洲小儿神经病学协会。由爱思唯尔有限公司出版。保留所有权利。
Multiple motor function and strength assessment tools exist for the evaluation of neuromuscular diseases, but most do not directly assess functional ability in the patients' daily physical activity in their home environment. In this study our aim was to assess: 1) the feasibility and accuracy of physical activity monitoring during two days in a home environment of five DMD patients using a non-commercialized monitor containing a 3D accelerometer and a gyroscope, 2) if a difference in the physical activity parameters could be measured before and one month after starting prednisolone. We reliably quantified the time spend sitting, standing, lying, walking, the number of steps taken, the cadence, the number of walking episodes and their duration as well as how these were distributed over the day. Parameters possibly reflecting endurance, such as the duration of the walking episodes or the succession of two or three walking episodes lasting more than 30 s were the most improved after prednisolone treatment. This degree of detailed determination of physical activity in a home environment has not been previously reported in neuromuscular disorders to our knowledge and some of the reported parameters are potential new outcome measures in clinical trials. (C) 2010 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.