Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.
Molecular basis of lipid antigen presentation by CD1d and recognition by natural killer T cells.
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DOI：
10.1111/j.1600-065x.2012.01166.x
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发表时间：
2012-11
影响因子：
8.7
通讯作者：
Zajonc DM
中科院分区：
文献类型：
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作者：
Girardi E;Zajonc DM
与多肽一起，T淋巴细胞对非经典CD1家族（CD1a-e）呈现的疏水分子（主要是脂质）产生反应。这些分子已经进化出复杂和多样的结合凹槽，以调查不同的细胞区室的自身和外源抗原，然后将其呈现给T细胞表面的T细胞受体（tcr）识别。特别是，大多数cd1呈递抗原被以自然杀伤T （NKT）细胞命名的淋巴细胞群识别，其特点是具有强大的免疫调节潜力。在NKT细胞中，根据它们的TCR库和抗原特异性，描述了两个主要亚群（I型和II型NKT细胞）。在这里，我们回顾了最近的结构和生化研究，这些研究揭示了I型和II型NKT细胞cd1d介导的抗原识别的分子细节，这在许多方面不同于肽mhc反应性tcr。
Together with peptides, T lymphocytes respond to hydrophobic molecules, mostly lipids, presented by the non-classical CD1 family (CD1a-e). These molecules have evolved complex and diverse binding grooves in order to survey different cellular compartments for self and exogenous antigens, which are then presented for recognition to T-cell receptors (TCRs) on the surface of T cells. In particular, most CD1d-presented antigens are recognized by a population of lymphocytes denominated natural killer T (NKT) cells, characterized by a strong immunomodulatory potential. Among NKT cells, two major subsets (type I and type II NKT cells) have been described, based on their TCR repertoire and antigen specificity. Here we review recent structural and biochemical studies that have shed light on the molecular details of CD1d-mediated antigen recognition by type I and II NKT cells, which are in many aspects distinct from what has been observed for peptide MHC-reactive TCRs.